In the "Once in a Lifetime" music video, Byrne appears in a large, empty white room, dressed in a suit, bowtie and glasses. In the background, inserted via bluescreen, footage of religious rituals or multiple Byrnes appear. Byrne dances erratically, imitating the movements of the rituals and moving in "spasmodic" full-body contortions. At the end of the video, a "normal" version of Byrne appears in a black room, dressed in a white, open-collared shirt without glasses.
