This is actually CSI Season 2 Episode 22 but also served as the pilot episode for CSI: Miami. In this episode, Grissom and his crew handle their highest profile case to date when the city's former chief of detectives is slain execution-style in his house following a wild party. Missing from the residence are the chief's trophy wife and their 7-year-old daughter. Catherine and Warrick follow the trail to Miami, and soon enlist the help of Horatio Caine.

Horatio Caine follows Henry Darius to New York so that he can keep his promise to a young boy in Miami, but by the time he and Mac are able to locate Darius he has disappeared again, leaving behind six more bodies. A link to the younger sister of one of the victims who was also Darius' hostage turns out to be a dead end, but Mac and Horatio soon find the connection between Darius and his hostage, leading them to a psychiatrist who had treated both.

(Crossover episode with CSI: NY, Season 6 Episode 7 and CSI: Crime Scene Investigation, Season 10 Episode 7.) Which presumably seemed to be a traffic accident, turns out leading to homicide and illegal organ harvesting. The chase of those involved in the slaughter chain makes all three NY, Vegas and Miami CSI teams put their efforts together to put an end to the crimes. Hawkes, in particular, is very upset about the case.

The third part of the triology:

Ray Langston is back in Las Vegas and still searching for Madeline Briggs after trying to find her in Miami and New York. At the same time, a local weather girl, Deedee, is found dead outside the Tangiers Hotel & Casino, dressed as a prostitute. When the team examines her, they discover Madeline's blood on Deedee's earring and an equally important tattoo. They theorize that Deedee and Madeline may have lived in the same place and shared the same pimp, so they go to a nightclub and spot another prostitute, Diane, with the same tattoo as Deedee. They arrest her on a bogus charge but get a lead when she calls her pimp from the station. The team follows her to a house where they see one of the pimps, Anthony Samuels, wearing the other earring seen on Madeline. Searching the house, Ray finds a bloody mattress and a lock box filled with money, casino chips and driver's licenses, including Deedee's. In the house, the team finds a badly beaten Diane. when they examine her, they find another tattoo covered over by Anthony. This leads the team to believe she used to belong to another pimp, Dmitri Sadesky, a Russian professor at nearby Western Las Vegas University (WLVU). Ray studies the mattress and finds definite matches to the blood of both Madeline and her unborn child. In the meantime, Catherine Willows reviews the security footage from the Tangiers to determine what really happened to Deedee. Catherine discovers that Diane is the murderer; Diane was jealous that Anthony preferred Deedee to her. Dmitri is caught with evidence in his car from the leg Ray and Horatio Caine found in Miami, and more dead women's bodies are found in the desert. With no other choice, Dmitri helps the team take down the human trafficking ring and admits he did have Madeline, but let her go because she was useless to him. Ray receives messages from Mac and Horatio; both have made crackdowns on the trafficking ring. Ray finds a way to send Madeline a text message saying her mother loves her in spite of everything that has happened. The message reaches Madeline, and she meets Ray outside the crime lab.