Set in modern Italy, Gunslinger Girl is the tragic tale of a group of young girls taken from hospitals from all over the country, who are cybernetically enhanced, brainwashed and trained to be assassins by a secret branch of the Public Corporation for Social Welfare. Each of the girls are assigned to a trainer, also known as their "brother" whom oversee their mechanized girl's training and the missions she's sent on. Hennreita, the newest girl to be brought to section 2, was discovered by her soon-to-be "brother" Josie after he found her in a hospitable, the victim of a serial homicide that left her the sole surviver of her family of six. Being new to the Public Corporation for Social Welfare himself, Josie is unskilled in the rearing of a mechanized body and he ends up treating Heneritta more like his daughter, buying her gifts, educating her and protecting her, far from the harsh measures that the other girls receive from their brothers who treat them more like an expendable machine.