Speedy Gonzales is summoned to help supply cheese for a Mexican mouse festival, and he makes repeated raids on a cheese store guarded by Sylvester Cat, whose attempts to stop Speedy become extreme.

Wile E. Coyote tries to catch the Road Runner using a sling shot, a grenade in a toy airplane whose propeller detaches and leaves the plane behind, a cannon on a cliff ledge that gives way, and axle grease on his feet that sends him into the path of a train driven by the Road Runner.

While on vacation, Bugs and Daffy take a wrong turn and get lost in the Himalayas. There they encounter the Abominable Snow Man, who happens to be looking for a pet, promising that he will "love him and hug him and call him George." Neither Bugs nor Daffy are too eager to become the object of his affection.

Wile E. Coyote chases the Road Runner with roller skis, a bow, a rifle, a boomerang, an anvil, and several exploding darts let loose from a balloon. The darts keep descending on the Coyote and exploding at inopportune times.

Bugs battles Wile E. Coyote. A ten trillion volt electric magnet draws everything imaginable.

Sylvester plays Mexican music on his flute in an attempt to catch all the mice. They can't resist the music so they come dancing out of their mouse hole, one at a time. Speedy is the only one who resists. Later in the cartoon Slowpoke Rodriguez comes to visit. He is hungry but is too slow to get food out of the kitchen without getting caught by Sylvester. Speedy goes for him but gets stuck in a glue trap set up by Sylvester. Lucky for him he had a bottle of tobasco sauce in his hand and when Sylvester lifts him up to eat him, the tobasco sauce poors into his mouth. The ""heat"" sends him through the roof and he gets badly injured and has a cast on his leg. At the end Speedy asks him if he wants his musical instrument back. He says no and Speedy says ""well, ok"". Then he starts playing the same music, forcing Sylvester to dance and hurt his already casted leg even more.

Daffy Duck vies with Porky Pig in the Western frontier hotel business. Porky has more success, attracting hordes of customers with a live-action saloon party. So, Daffy decides to "undermine" Porky's good fortune by planting a bomb beneath Porky's inn.

Wile E. Coyote tries and fails to catch the Road Runner using his foot extended to trip, an arrow, a hole in the road, a winged-rocket outfit, two electronically activated machine guns, and a super magnet.

Sylvester Cat slips when making a grab for Tweety Bird in Granny's flat, and falls dazed to the floor as one of Tweety's feathers lands in his mouth. Tweety runs off. Sylvester comes to and finds the feather lodged between his lips. He thinks he has swallowed and killed Tweety and suffers terrible remorse as an Alfred Hitchcock-like voice-over chides him for his "crime". Sylvester cracks, runs into the streets confessing, and returns to Granny's place, where he finds he didn't eat Tweety after all.