The show focused on two life-long friends, Sanford and Del, and their adventures at the fictional Barder College. With the exception of their roommate Joe, everyone on campus is incredibly stupid and inept. Nonetheless, the idiotic, irresponsible, and thoughtless Sanford and Del are portrayed as the series' heroes, whereas the responsible, level-headed, greatly intelligent Joe is the de-facto villain in most episodes, occupying a "Frank Burns"-esque role on the show. The series was created by Family Guy veteran writer Mark Hentemann, based on a short film he had created years earlier. It is to-date the only animated series produced for MTV by Warner Bros. Animation.
Sanford and Del discover that they've missed the first 3 weeks of classes, and will flunk out unless they pass an upcoming biology test.
Joe thinks that his new invention might save the Dean's job -- and allow Joe to transfer to a better school.
When one of his classes is moved to a new time, Del starts hanging out with a different group and becomes a Big Man on Campus.
When Todd loses his job as RA, who better to take over than Sanford?
Sanford gets Del to stop being a mama's boy. And almost kills him.
Joe finds out he's in the wrong dorm room and has to moved to the single house he was originally supposed to have.
Joe is desperate to transfer out of Barder while Del and Sanford are desperate for Coke (a-Cola that is).
Barder's annual Midnight Yell gets Sanford and Del to freak out.
Joe finds out the only thing harder than getting kicked out of the worst college in the country is trying to get back in.
How do you top an alumni prank? Kidnap a school mascot, that's how! Unfortunately, Del and Sanford steal their own school mascot!
When Sanford and Del get dates with a couple of girls from a sority to their sorority party Joe gets jeolous and starts working out but soon finds out the real reason Sanford, Del and many others were invited.
Sanford and Del loose all their money in a poker game to Moe so they sell their weekend school meals for 500 dollars they buy a 500 dollar safe to put their money in. When they realize they spent all the money on the safe they sell the safe back to the store for 10 dollars. When they realize they can't eat on weekends because of that they steal 2 chickens, with the help of Ed, so the Chickens will lay eggs and they can eat them. When the Chickens don't lay eggs they hold a cock fight in their dorm room. Meanwhile Joe searches the dorm to find a room where he can study in piece and quiet. When he finds this place he meets Max who he becomes best friend with him until the end in a bizarre ending.