Deputy Police Chief Brenda Leigh Johnson (Kyra Sedgwick) is a police detective who transfers from Atlanta to Los Angeles to head up a special unit of the LAPD that handles sensitive, high-profile murder cases. Despite a tendency to step on people's toes, Johnson manages to convert even her strongest adversaries with her unique ability to get to the truth.
Things don't add up when an LA cop turns up dead. Brenda and her team race against the clock to get to the truth, while tension increases between the Priority Homicide Division and the Robbery-Homicide Division. In the meantime, Brenda's relationship with Fritz elevates to a whole new level.
When a juror in the trial of an infamous mobster is found dead, Brenda and the Priority Homicide Division find that their involvement in solving the case may be affecting the jury's final decision. Complicating her personal life, Brenda faces another new challenge: a surprise visit from her mother.
Things are not as they seem when Brenda and the team investigate the accidental murders of three college students caught in the middle of a gang shootout. Brenda must also continue her attempts at keeping her relationship with Fritz under wraps while her mother remains in town.
Brenda and the PHD investigate a high-profile case when a woman is brutally murdered at L.A.'s trendiest restaurant. On the home front, Brenda tries to keep a low profile as she closes in on her 40th birthday.
Brenda finds herself involved in a cover-up of her own when she helps the PHD investigate a non-priority case. Why? Because the deceased woman was found in Provenza's garage. Once again, the team finds themselves racing against the clock before the LAPD brass discovers what they're up to. Will Brenda be able to protect her team and their hard-earned trust?
Brenda and the team find themselves wading through a long list of suspects when a celebrity photographer takes a fatal fall from his hotel room balcony. Once the cause of death is determined, the motive points to a big time actor with something to hide. In the meantime, Brenda starts to feel like Fritz is behaving strangely, making her realize that superstars may not be the only ones who have secrets to keep.
When a few body parts of an "adult film" star are found in a dumpster, Brenda and the team must scramble for more pieces to solve this puzzle. Once they begin putting things together, the suspect list seems to get longer. Adding more questions to her life, Brenda also finds herself making a potentially life-altering discovery.
When the drowned bodies of a mother and daughter are found by fishermen, Brenda and the team must determine if the apparent suicides are more than that. Following a strange coil of discoveries, the most surprising revelation that surfaces is one about the killer.
When a young boy blames himself for the death of his friend, Brenda must tread lightly to get to the bottom of the case. Complicating matters is the deceased child's mother, who offers up accusations of her own.
The PHD must deal with a case of mistaken identity in order to get to the bottom of an investigation. While they're busy with the case, Brenda is involved in a different case: Pope's divorce. After being called to testify, Brenda finds that both her career and reputation are on the line.
Leaving the scene of an accident to get to a multiple homicide scene, Brenda finds herself unable to drive the streets of L.A. which she worked so hard to learn. Once she gets to the crime scene, she and the PHD are faced with another challenge: the murdered bodies are nowhere to be found. In order to solve this case, they must first search for the victims before they can hunt for the killer.
Once again, the PHD finds themselves wading through suspects in the murder of the star witness in a capital punishment case. When Estelle, Pope's angry ex-wife, spills the beans about Brenda to her team, Fritz begins to wonder how she really feels.
Brenda and Fritz have a hard time agreeing who is in charge when an informant's wife and and FBI agent are both murdered. Brenda discovers that she and the PHD must work quickly when the leading witness in the case is scheduled to testify against a powerful mobster. When the killer's identity is uncovered, the PHD finds themselves under attack; an attack that takes someone down.
Resulting from the showdown in the murder room, Brenda finds herself taking some involuntary time off. When she is asked to help a friend solve a murder that is linked to a terrorist group, Brenda works to find the killer and still keep it under wraps. Meanwhile, Commander Taylor jumps at the chance to break apart the PHD while Brenda is away.
Glad to be back with her team, Brenda focuses on finding a terrorist-linked suspect. Working with the CIA, who also wants their hands on this suspect, Brenda realizes that she was given false information, and wonders if she's been set up.To prevent herself and the PHD from falling prey to a sinister plan, Brenda must untangle a web of lies to determine who she can trust - before it's too late.