From Mad About You co-creator and executive producer Danny Jacobson (Roseanne) comes a comedy about a young threesome as they approach life, love and friendship on their way to adulthood. Portrayed by a talented breakout cast. The "two guys" are Berg and Pete who share an apartment and support themselves by delivering pizza from Beacon Street Pizza run by Bill (Julius Carry) who was only around for the 1st Season. In the first years of medical school, Berg (Ryan Reynolds) had a cavalier approach to life and women but now finds himself with Ashley, a fellow med student. Berg is generally happy about this relationship, but it has its ups and downs - that's what makes it so much fun. Pete (Richard Ruccolo) has abandoned his plans to become an architect and is searching for a career Sharon (Traylor Howard) is "the girl" - the upstairs neighbor who hates being a chemical saleswoman although she can't complain about the benefits, including a hefty salary and a shining "Beemer." Sharon's boyfriend Johnny (Nathan Fillion) adores her, but she's not sure what she wants... maybe it's because she's already met the ideal man but doesn't know it. For now, she enjoys being part of a special threesome enjoying life no matter how unbelievable it can really be.
Pete wants to break up with his girlfriend Melissa because he doesn't think, ""she's the one""; however, just as he's deciding against it, Berg tells Melissa.
Pete, who has a big presentation to make in front of the museum board, might have accidentally swallowed an overdose of an allergesic Berg is testing out.
Pete and Berg, who feel neglected by Sharon since she has a new boyfriend, plan to sabotage her relationship.
Pete, a huge Boston Celtics fan, is extremely jealous of Berg when Berg gets to sit on the bench with the Celtics. Berg tries to cheer him up by ""borrowing"" the Celtics championship banner.
Berg and Sharon make it their business to interview possible future tenants when a vacancy opens up in their building. Pete tries to figure out what to get Melissa for their one-year anniversary, and Berg has a severe emotional reaction to his latest experimental product.
Berg and Pete start a co-ed baseball team in order to meet more women. Bill, being their sponsor is led to believe that team is actually good and challenges one of his competitors to a game.
Berg sets Pete up with a patient at the hospital called Lauren in an effort to get Pete over his recent breakup with Melissa. It's only when Pete starts to really like her and starts calling her ""The One"" that Berg finds out she may not have long to live. It turns out though that Lauren is not dieing, but she does live in Colorado. In the end, Pete is glad that he's been dumped by Lauren because it made him forget about Melissa which means he's ready to start dating again.
Berg throws 24 year-old Pete a fake 30th birthday party so he can meet a woman he's had a thing for years. Meanwhile, Sharon awaits a call back from a guy she really likes, unaware that he already has.
Berg and Sharon set Pete up with a girl they find listed in the personal ads, but she soon makes it clear she won't let anyone come between them, even to come in Berg's bedroom at night with a baseball bat.
Berg gets suspicious of Pete when he always want's to deliver the pizza to 845 Arlington. So Berg makes the delivery for a change and discovers that it's a gorgeous artist who paints with her nude body that's been making the orders. This leads Berg and Sharon to believe that Pete is cheating on Melissa with her.
Pete and Berg reflect on their college days when Bill asks them how come neither of them was ever romantically involved with Sharon.
Pete is trusted to keep the fact that Berg's dad has quit his law firm to become a caricaturist in the park from Berg and that Berg is no longer in law school from Berg's father.
Pete and Berg fight back against their landlord when he goes over the edge with the rules for living in the building.