Level headed Mike Miller runs Desert Airport, an air mail base full of daring young pilots risking their lives to get the mail through-regardless of the weather. Following the death of one pilot in a horrific crash, Miller is forced to engage the wild and arrogant, yet skillful, Duke Talbot. When pilot Dizzy Wilkins crashes and dies in a storm, Talbot runs off with the young Mrs.Wilkins, leaving Miller to complete the last leg of Wilkins' mail run. Miller crashes on a mountain. Alive but in an inaccessible location, Miller tries to endure his injuries while futile attempts are made by air mail pilots to rescue him. Hearing of the impossibility of reaching Miller's crash site in time to save him, Talbot can't resist the challenge of trying an airborne rescue himself.