Dr. Mike, Sully and the family travel to Boston for an adventure they'll never forget.
Michaela and Sully travel by train to Boston with their children Brian and Katie to be at Colleen's graduation. Upon arriving they find that Michaela's mother just about to be released from the hospital but instructed that she needs complete bedrest. Colleen must face the fact that a woman doctor will not be welcomed at any Boston medical office. Brian gets a job while everyone is busy with Colleen's graduation and his Grandmother's failing health.