Buck Bonham (Willie Nelson) is a country singer, with a good family, struggling to find national fame. He juggles his music career with his responsibilities to his wife (Dyan Cannon) and son. He has everything going his way until the daughter (Amy Irving) of his former guitarist joins his tour. Having her on the road leads to temptation. That leads to a crisis with home and family. After Willie Nelson's theme song "On the Road Again" became a hit and an Oscar contender, the film was re-released under that title.