Tough-talking Nicky Hambleton-Jones returns to preside over the rejuvenation A-team: cosmetic surgeon Jan Stanek, cosmetic dentist Surinder Hundle, hair stylist Andrew Barton and make-up artist Ruby Hammer.
Dr Sarah Widd has been too busy living her hectic lifestyle to spend any time on herself. She's not visited a hair salon for nearly 35 years and even opted to have all of her top teeth pulled out to avoid repeated visits to the dentist.
Jackie Robinson is horrified when 100 supermarket shoppers judge her to be 11 years older than she really is.
Thanks to a 20-a-day smoking habit - that's 200,000 fags over 30 years - 52-year-old Pandora looks old beyond her years.
While some women were dreaming of jewellery or shoes at Christmas, top of Angela Mattock's list was a brand new face.
Bev Hawkins from Suffolk may be the same age as Madonna - but that's about all they have in common. While Madge can slink around in sexy clothes to show off her super-toned body, Bev suffers from an affliction which could only be called 'mutton dressed as lamb'.
Jeanette Quinn from Manchester has paid the price for a party animal life. If she spent as much time applying moisturiser as she had clubbing, maybe she would look her age - instead of ten years older.
Grandmother Terri Wardner from Southampton is horrified when 100 passengers aboard a cruise ship guess she is 64 years old.
Sun worship is a religion that requires sacrifices: 10 years of scorching solar rays has taken away the elasticity and radiance of Cathy's skin, leaving her with a thinning, baggy and mottled complexion.
With his long, greying locks and bushy beard, DJ and music entrepreneur Simon Dehany takes his style cues from the Bible.
Mature architecture student Janice Despard from Glasgow had been in pursuit of a tan for longer that she can remember.
Looking after herself is low on Louise Chambers' priority list. She much prefers roaring around Bognor on her motorbike.
Ruth, 34, from Sapcote in Leicestershire had been overweight as a child and reached a massive 19.5 stone after her second pregnancy. Dramatic weight loss surgery has reduced her body by a whopping nine and half stone and she's now a sexy size 10.
Childminder Julie Davis from Worthing, Sussex was no yummy mummy at the school-gates. Years of trekking backwards and forwards to school with 12 children each day in all weathers had left her with some serious wrinkles.
Salena Newport from Oxfordshire dropped off the fashion radar a long time ago. At one point in her yo-yo dieting life, she wore a massive size 32 clothes.
Senior nurse Liz Tewnion is obsessed by her turkey neck, according to her husband. It's an obsession that has turned her from a carefree party girl to a shy, retiring mouse.
School secretary Linda Strallen is the dress size many women would diet for - a tiny size eight. But rather then show off her petite figure, Linda chooses to wear children's clothes. Boys' clothes.
The 10 Years Younger team finish their look back at some of their favourite makeovers by catching up with Jeni Ingram who went from drab to diva. Two years on is Jeni still looking as good?
Nicky Hambleton-Jones is back to catch up on one of her favourite and most incredible transformations. Two years on is Nerys McGarry still looking as fabulous?