Yakumo and Pai return to Japan from Hong Kong after the Statue of Humanity disappears from the mysterious Mrs. Huang's mansion. Yakumo returns to school and his friends in the hopes of resuming a normal life. But nothing is normal when you're an undead zombie bound to a magical being and demons start attacking your schoolmates on the playground!
Yakumo and Pai return to Hong Kong when the Statue of Humanity turns up in the possession of Steve Long, another Monster Buster, Inc colleague. Before they can reach it, Steve and the statue are kidnapped. Yakumo, Pai, Ling Ling, and Steve's sister Meixing attempt a rescue. But it's all a trap to catch Pai, the statue, and Meixing in a human sacrifice to release the dark spirit of Kaiyan Wang!
Yakumo, Pai, and the crew of Monster Buster, Inc celebrate their recapture of the statue at Madame Huang's estate, but the party is spoiled by a gruesome challenge delivered by a powerful Wu of Kaiyan Wang's. Pai meets the Wu for a showdown at Aberdeen Harbor and half the harbor is destroyed in the aftermath. How will Yakumo continue on without the anchor of his life?