Jeff Fisher and the Rams make the big move from St. Louis to Los Angeles, and the big move up in the Draft to select quarterback Jared Goff, who joins stars Todd Gurley and Aaron Donald as the Rams begin their 2016 season trying to win over a city and a fan base.
The Rams celebrate their first home game at the LA Memorial Coliseum in nearly 40 years, before travelling to Tampa to face the Buccaneers in a high-scoring affair interrupted by a lightning storm.
In his bid to hold off rookie Jared Goff, veteran quarterback Case Keenum looks to keep the Rams on a roll as they face their division rivals, the Arizona Cardinals.
Injuries begin to mount as the NFL's road warriors pack up for a two-week, 11,000-mile road trip, first to Detroit to take on the Lions and then to England to face the Giants - a trip that gives the players and their families a chance to see the sights and sounds of London.
Star defensive tackle Aaron Donald leads a dominant defense against the Panthers, Jets and Dolphins, but poor offensive play and growing criticism force the team to make a difficult choice.
It's Jared Goff time in LA, as the Rams try to salvage their season... and their head coach's job.
After being named Interim Head Coach, John Fassel leads the Rams through the final weeks of the season and into an uncertain future.