Archer follows the exploits of eight dysfunctional secret agents of the International Secret Intelligence Service (ISIS), a fictional New York-based intelligence agency. They are : Sterling Archer, the show's narcissistic, womanizing protagonist, Malory Archer, ISIS director and Sterling's snarky, emotionally distant mother, Lana Kane, Sterling's love interest and mother of his infant daughter, and by far the most professional field agent at ISIS, Ray Gillette, the agency's openly gay bomb specialist, Pam Poovey, the head of the agency's Human Resources department who is often ridiculed by her peers, Cyril Figgis, a mild-mannered accountant-turned-agent, Cheryl Tunt, Malory's delusional, psychotic personal assistant and Dr. Algernop Krieger, a bizarre, morally bankrupt scientist with little regard for the well-being of his subjects.
Archer is shocked to learn that his mother is dating Archer's idol/hero/man-crush, Burt Reynolds.
Cyril is promoted to field agent, while Malory institutes a strict drug-testing policy. Neither of which sit well with the staff of ISIS.
The Royal Canadian Mounted Police enlist the help of ISIS to transport a captured Canadian terrorist. On a train.
Archer's surprise birthday present - a high-tech, souped-up spy car - leads to all sorts of other surprises. None of which are good.
Malory turns to Archer and Lana for help when she finds herself in a compromising situation with the Italian prime minister.
Archer must help Gillette save his younger brother from a crooked sheriff in the backwoods of West Virginia.
Archer's sex life compromises his effectiveness as an agent. But more seriously than the countless other times.
Archer is faced with a dilemma when his murdered fiance, Katya, miraculously reappears. In Krieger's lab.
Archer and his colleagues at ISIS voyage to the final frontier in an effort to prevent a catastrophe on the International Space Station.