Bob Newhart plays Bob McKay, a greeting card artist, whose 1950’s comic book, Mad Dog, was forced into oblivion when a Senate sub-committee deemed that his comic was corrupting to his young audience. However, years later, The American-Canadian Trans-Continental Communications Company, a.k.a. AmCanTranConComCo buys the rights to the series and wants a comeback. Conflicts arise however when head Howard Stone wants to retool it and make Mad Dog a vigilante.
With the demise of Mad-Dog Comics, Bob is hired back to run a greeting-card company.
Sylvia the McKay's over and tries to fix up Pete and Trisha.
Pete wants to be an artist instead of a salesman, so he steals Trisha's idea and tells Bob it's his own.
Host Bob has trouble writing a speech for an awards ceremony, meanwhile Sylvia debates if she should attend or not because her ex-husband might be at the award ceremony.
Bob and Pete go on a sales trip and Bob spends the entire evening dodging the sexual advances of his potential client, Joyce Leona-Curtis, although Pete doesn't believe it.
Pete fixes Sylvia up with a notorious ladies' man, Buzz Loudermilk.
Whitey loses an engagement ring among Christmas presents for orphans.
The dental hygienist who ran off with Sylvia's husband returns to town, and Sylvia decides to confront her.