Sick, twisted, politically incorrect and Freakin' Sweet animated series featuring the adventures of the dysfunctional Griffin family. Bumbling Peter and long-suffering Lois have three kids. Stewie (a brilliant but sadistic baby bent on killing his mother and taking over the world), Meg (the oldest, and is the most unpopular girl in town) and Chris (the middle kid, he's not very bright but has a passion for movies). The final member of the family is Brian - a talking dog and much more than a pet, he keeps Stewie in check whilst sipping Martinis and sorting through his own life issues.
Brian takes a job on the police force as a drug-sniffing dog, which leads him down a path of cocaine addiction. Trying to kick the habit, Brian checks into a clinic. With the Griffin family cruise canceled due to Brian’s absence, Peter gets the idea to vacation at the rehab retreat.
The Griffin family learns Brain has gone to Hollywood. After trying out on Kids Say the Darndest Things, Stewie awarded an appearance, and the Griffin get a free trip to Los Angeles. Brian doesn't want the family to know what he's really doing in Hollywood, and tries to cover it up.
Peter's toy company gets bought out by the El Dorado Cigarettes company, and the toys are then used to market cigarettes to children. When Peter, on Lois's advice, confronts his new bosses about their evil use of toys, they promote Peter to president to shut him up. Lois, pleased with all the perks that come with Peter's new position, keeps her mouth shut too, while Brian quits smoking in protest. Peter's bosses send him to Washington to lobby against a bill that would put them out of business, because they figure politicians will be able to relate to a big dumb fat guy. When Lois finds Stewie smoking a cigarette, she goes down to Washington to stop what Peter's doing, and Peter ends up getting the El Dorado Cigarettes company fined $100,000,000. Brian helps himself to a cigarette as the family drives away.
When a hurricane strikes Quohog, everything is destroyed including The Drunken Clam, which is bought out by a Brit who turns it into an English pub. As it happens, pub owner Nigel Pinchley and his family move in next door to the Griffins, and Stewie tries to teach Nigel's Cockney-accented 3-year-old daughter how to speak proper English.
Peter feels jealous when he finds out Chris has a larger penis than he does, so he tries various tactics like buying a new car and joining a gun club. He then takes Chris on a father-son hunting trip only for Chris to eventually save the day.
Meanwhile, Meg finds herself to be a target of abuse from the cool kids at school when she joins the flag girl squad.
Peter sneaks away on his and Lois' anniversary to play golf at an upscale country club, only to be struck by lightning and have a near-death experience. Death promises to give Peter a revelation to help his marriage if Peter helps him get a date.
Meanwhile, Peter sets up a fake scavenger hunt for Lois and the kids, which takes them all over Quahog.
Bonnie convinces Lois to join her Tae-Jitsu class and Quahog is invaded by New York "leafers" coming to look at the pretty colored leaves in fall. Lois quickly becomes a black-belt, and Peter uses his new dangerous wife to drive away all the annoying New Yorkers. However, Lois' new-found violent side finds its way into the Griffin household, and after trying counseling, the whole family has an all-out brawl to get it out of their system.
When Meg, due to her crush on Tom Tucker, the newscaster, applies for an internship at the local television station and gets the job, she is disappointed to find that her news partner is the most reviled nerd in school, Neil. Caught in a life-threatening news situation, Meg laments that she never had a first kiss and agrees to kiss Neil only to find that he taped the whole thing in order to broadcast it across the world. Meg broadcasts her own news that she has no interest in Neil, sending him to the ledge on top of Town Hall. She breaks his fall, only to find out that he had no intention of jumping and was just trying to get her attention again. Stewie's prized new tricycle is stolen by the neighborhood bully, but the bully soon learns not to screw with Stewie.
Peter's boss comes to dinner at the Griffin house but soon dies. The Happy-Go-Lucky Toy Factory is turned into the Happy-Go-Lucky Terminal Disease Institute. Unemployed, Peter begins his search for a job and ends up going after his lifelong dream of becoming a knight at a traveling Renaissance Fair. Caught in a compromising position with the infamous Black Knight's wench, he must defend his family's honor in an duel with the Black Knight.
Peter, Still out of a job, and now severely obese, decides to take on a new profession: Fishing. After buying a boat at a police auction, he soon finds himself in debt to a loan shark. When Peter hears of a legendary fish that, when caught, could win him the money he needs, he and the guys go searching for the mystical creature called 'Daggermouth'. Meanwhile, Lois tries to cheer up Meg with a spring break trip, where Lois is the one getting all the attention.
Peter goes with Lois to visit her sister Carole, who is now pregnant, but alone since her husband walked out on her. Carole goes into labor and Peter helps deliver the baby. Caught up in the moment, Peter and Lois decide that they want another baby. Stewie however, does not agree. Stewie does everything possible to keep Peter and Lois away from each other, but when he is locked out of their room, he is forced to take desperate measures. Stewie ends up shrinking himself down to microscopic size and seeking out his sperm-brother inside Peter's body. Instead of trying to kill his unborn brother Stewie and him unite to destroy Lois.
Chris chooses a robber out of a lineup, but after Peter accidentally tells the robber where the family lives, the Griffins are placed in the witness protection program. They are sent to the Deep South, where Chris makes a new friend, Sam. Peter questions the truth of a Civil War reenactment that showed the South winning the war, leading to Sam's father forbidding Sam from seeing Chris. Upset, Sam runs away with Chris and kisses him on the mouth. Chris tells Sam that he doesn't like boys and doesn't like him in a physical sense. The FBI agents guarding the Griffin house in Quahog accidentally tell the robber the location of the Griffins. Sam reveals to Chris that she is not a boy, but a girl. Then the robber arrives in the South, about to kill Chris, but the towns folk stop him just in time.
Peter and Lois go to the Pewterschmidts for the weekend, bringing Brian along. Brian, meanwhile, has some "issues" of his own to work out. Find out if Brian's future is to make puppies or become "less" than he is.
While trying to teach Chris about his Irish roots, Peter stumbles upon Nate Griffin, a black man in his family tree. Peter tries to embrace his new-found heritage, but can’t quite get the hang of it. When Lois’ father, Carter Pewtershmidt, sits the Griffin kids down for a look at his family genealogy, a dark secret is uncovered.
Joe gets discouraged, losing his self-confidence, after he loses a thief in a chase. Peter wants to help Joe get back to his old self so he volunteers to help train him for the decathlon at the Olympics for handicapped athletes. Peter puts steroids into Joe's drink, pushing Joe on to victory. Meanwhile, Stewie, Meg, and Brian fight over $26.
Christmas comes to Quahog! While Lois attempt to make the holidays perfect for the Griffin family, Peter messes it up. Meanwhile, Stewie learns of Santa Claus’ ability to keep 24-hour surveillance on all the world’s children.
When Brian is arrested for drunk driving, he's forced to do community service, which consists of helping Pearl, a middle-aged, agoraphobic, bitter woman. Brian gets so fed up with her insanity, that he storms out of her house. Later, Brian watches a television documentary that reveals Pearl's past as a top advertising jingle singer of the 1950s and 60s. Brian warms up to her, realizing where her pain comes from, and eventually she warms up to him too. He convinces Pearl to actually go outside, but she gets by a bus. While on her deathbed, Brian and Pearl share a fantasy intimate moment, but as they are about to kiss, she dies.
Meanwhile, Peter grows a beard and learns that a swallow has nested inside it. He wants to shave it off but can't when he finds out the bird is an endangered species. Peter eventually grows attached to the bird and starts feeling maternal. Lois is finally able to convince Peter to let the bird fly away and also teaches Brian about moving on with his life after Pearl's death.
When Brian expresses his interest in theatre, Lois tells him to try out for the Quahog School of Performing Arts. During the audition, Brian turns in a mediocre performance and is dismissed by the judges. Stewie, determined to get Brian a second chance, throws a melodramatic fit. The teachers, impressed with Stewie's theatrics, enroll him in the rising stars program. Stewie doesn't realize he is struggling at the school until he overhears his teachers discussing how he and Olivia, the school's most promising but overly haughty student. will be asked to leave if they don't shine in the quarterly review. Stewie tells Olivia that they must put on the performance of a lifetime or they'll get kicked out, and their routine is a hit. Stewie and Olivia become fast friends, but the harmony ends when competition, pressure and fast-fame set in. Olivia walks off the stage mid-routine, leaving Stewie to finish the performance. Stewie takes his act solo, but is booed everywhere he goes.
Meanwhile Meg finally gets a boyfriend, a boy from an all-American family. There's only one problem with this family though - they're nudists.
Peter's jealousy reaches new heights when he accompanies Lois to the gynecologist. As the doctor prepares to examine Lois, Peter refuses to let him near her. Later, while shopping, Lois runs into an ex-boyfriend, Ross Fishman, who innocently asks her out for coffee. Fearful of Peter over-reacting, Lois sneaks off to meet Ross. At the same time, Joe picks up Peter for a joyride in his new high-tech surveillance van. While parked outside a diner, they see Lois and Ross inside. Using the van's high-tech gadgets, Peter misinterprets Lois and Ross' words. Angered, Peter decides to make Lois jealous by hiring prostitutes to pose as his ex-girlfriends. Realizing their marriage needs help, Lois and Peter see a marriage therapist, who suggests placing video cameras around the house for a week. After viewing the tapes, the therapist recommends that Peter and Lois date other people during a trial separation. Quagmire, hoping to take advantage of Lois' vulnerability, invites her on a date to a restaurant where they run into Peter and his gorgeous date, Jennifer Love Hewitt. Lois becomes enraged with jealousy and shoos Peter's date away. They leave together happily.
Meanwhile, Stewie and Brian accidentally super glue themselves together at the store. They have to wait a week before the solvent arrives in the mail. While stuck together, they actually begin to like one another. Of course, things return to normal the moment they're released from their glued prison.
Stewie is addicted to the British hot children's show "Jolly Farm Review" based on Mother Maggie, a benevolent figure who looks after kids on a farm. Brian makes fun of Stewie for watching the show, but Stewie is determined to visit Jolly Farm in England because he thinks he belongs there. He stows away on a British Airways jet, which he assumes is headed for London. Brian tries to drag Stewie off the plane, but before he can, the plane takes off. When the plane lands, they discover that they are in Saudi Arabia are stranded in the middle of a desert with no passports or resources to get out. As luck would have it, Brian and Stewie encounter a Comfort Inn in the middle of nowhere and manage to steal a hot-air balloon to fly home, but the contraption falls apart over Italy, just as the Pope is about to address the masses. Brian wants to head home, but Stewie insists on finding the Jolly Farm in England. When they finally get to England, Stewie runs onto the set of the show. His fantasy is crushed when he encounters only a set full of props and disgruntled people, including Mother Maggie.
Meanwhile, Lois and Peter travel to KISS-stock, where Lois embarrasses herself because she doesn't know the lyrics to a KISS song. She redeems herself though when it's revealed that she once hooked up with band leader Gene Simmons!
In a special three-story episode, Brian reads viewer mail and tries to answer profound questions:
The Griffins as the little rascals. Kid versions of Peter, Joe, and Brian decide that they don't need girls. When they first meet Lois however, they quickly abandon their anti-girl sentiment. In school, Lois reads a book touting the virtues of bravery, and Peter and Quagmire try to prove who's the bravest by staying in a haunted house overnight.
"No Bones About it"
Peter rubs a beer bottle and a Genie pops out to grant him three wishes. Peter first wishes that Jackie Gleason wasn't dead. A zombie-like Gleason terrorizes the Griffins until Stewie blasts it dead. Peter then wishes he didn't have any bones. The Genie transforms him into a gelatin blob and he can no longer have sex. Upset, Peter flushes himself down the toilet and winds up in Hollywood. He meets a doctor who tells him about a re-boning procedure. Peter gets the operation, which turns out came from bones donated from his own family.
A tanker truck containing radioactive waste slams into the Griffin house. The radiation affects each Griffin in a different way. Lois gains super strength while Peter has morphing ability. Lois tells her family that they must not abuse their powers. Of course that doesn't work and the town is forced to hold a meeting to see how to stop the Griffins from wreaking havoc. Adam West realizes he must fight fire with fire. He volunteers to roll around in toxic waste but he only gets lymphoma as a result. The Griffins, racked with guilt, use their powers to make Adam's recovery more comfortable.
The day that Peter buys volcano insurance is the day that Lois becomes fed up with their constant money problems. When Peter wishes for a Jewish "money guy" to help them, Max Weinstein comes to the rescue. After meeting Max, Peter decides Chris could be successful if he converted to Judaism as soon as possible, but the plans for a "quickie" bar mitzvah in Las Vegas are quickly foiled by Lois.