Sick, twisted, politically incorrect and Freakin' Sweet animated series featuring the adventures of the dysfunctional Griffin family. Bumbling Peter and long-suffering Lois have three kids. Stewie (a brilliant but sadistic baby bent on killing his mother and taking over the world), Meg (the oldest, and is the most unpopular girl in town) and Chris (the middle kid, he's not very bright but has a passion for movies). The final member of the family is Brian - a talking dog and much more than a pet, he keeps Stewie in check whilst sipping Martinis and sorting through his own life issues.
In this murder mystery special, The Griffins as well as all the other major characters become trapped in a mansion while they are killed off one by one.
When Brian learns that Rush Limbaugh is going to be at the Quahog Mall for a book-signing, he decides to go down there and give him a piece of his left-wing mind. But when Rush unexpectedly comes to Brian's rescue, Brian has a political change of heart.
After Peter catches Carter having an affair, he is forced into keeping a secret. But when Peter accidentally spills the beans, Lois' mom demands a divorce, and Peter is in charge of Carter's return to bachelorhood.
Peter and Joe team up to execute a series of painful and humiliating Halloween pranks on unsuspecting family, friends and neighbors. While Brian shows Stewie the ropes of trick-or-treating, Meg sets out to attend her first high school Halloween party with high hopes for the evening.
When Peter receives tickets to a boxing match as a birthday gift, he volunteers Lois to compete. To everyone’s surprise, Lois dominates in the ring, and Peter decides to become her fight promoter. Her frustration with Peter turns into motivation in the ring as the housewife turns champion
Feeling discouraged with the progress of his writing career, Brian decides to throw in the towel until Stewie become his manager and one of his books hits the bestseller list. But when the fame goes to his head, Brian gets a wake-up call from Bill Maher.
Stewie’s favorite thing after his teddy bear, Rupert, is Christmas. So when he hears that Santa is making an appearance at the mall, he begs Brian to take him so that he can tell Santa in person what he wants for Christmas. Brian begrudgingly takes Stewie to the mall, only to get the brush-off from Santa. As a result, Stewie and Brian travel to the North Pole to find Santa and teach him a lesson in holiday cheer.
Peter needs a new kidney after his energy-drink addiction causes renal failure. Meanwhile, Chris is chosen to introduce United States President Barack Obama at his school after winning an essay contest. Trouble is, Meg wrote the essay.
Lois is forced to defend her reputation after the new local news anchor (Christine Lakin) does a story on her.
Brian and Peter are required to attend a 12-step program to deal with their drinking problems; Death (Adam Carolla) gives Peter a glimpse of what life would be like without alcohol.
On the search to find a new hobby, Chris meets a puppeteer named Franz, an old friend of Herbert’s.
Meg offers to check on Joe while Bonnie is out of town; Stewie tries to become more evil.
Chris and Meg think their parents have it easy, but Peter and Lois beg to differ, so in order to teach them a lesson, they all trade roles. Chris goes to work at the brewery while Meg runs the house.
When the local dry cleaner loses Peter’s favorite white shirt, he goes ballistic. Meanwhile, Brian tries to score on a date with a new friend, Denise (guest voice Stroup), but ends up striking out.
When Mayor West marries Lois’ sister, Carol (guest voice Hagerty), they move into the Griffin’s house to be one big “happy” family.
Stewie and Brian go back in time to stop Bertram from killing Leonardo da Vinci
Bonnie and Lois take a little trip to Paris, but Bonnie crosses the line in the City of Love. Meanwhile, Peter home schools Chris and Meg using some unorthodox teaching methods.
In this spectacular and offensively uproarious final chapter, Luke Skywalker (Chris) and Princess Leia (Lois) must travel to Tatooine to free Han Solo (Peter) by infiltrating the wretched stronghold of Jabba the Hutt (Joe), the galaxy's most loathsome and dreadful gangster. Reunited, the Rebels team up with a tribe of Ewoks to combat the Imperial forces on the forest moon of Endor. Meanwhile the Emperor (Carter Pewterschmidt) and Darth Vader (Stewie) conspire to turn Luke to the dark side, and young Skywalker is determined to rekindle the spirit of the Jedi within his father. The Galactic Civil War has never been more outrageous, as the Rebel forces gather to attack the seemingly defenseless and incomplete second Death Star in the battle that will determine the fate of the galaxy.