In the fifth season, Bender grows jealous when Fry attempts to clone his beloved fossilized dog; when Kif gets pregnant, Amy questions her readiness to become a parent; when Fry and Leela discover a mysterious cream that gives them unusual powers, they form a Superhero team along with Bender; and Fry makes a deal with the Robot Devil so he can become a skillful musician and win Leela's heart.
The rapid increase in global warming is traced to a ventilation flaw that Professor Farnsworth failed to correct in his first robot prototype. As a result, all robots are ordered to be destroyed, but Bender refuses to go without a fight.
Fry discovers his dog Seymour is being exhibited in a museum as a fossil, and takes it to Professor Farnsworth's lab to be revived. However, Bender is displeased with the lack of attention he has been receiving and becomes increasingly jealous of Seymour's fossil.
Farnsworth's clone Cubert teams up with Hermes' son Dwight to launch a newspaper delivery business. Farnsworth and Hermes scoff at the kids' efforts - until the delivery boys accumulate enough capital to buy out Planet Express. Meanwhile, Fry and Leela use Bender to brew their own homemade beer.
When Zoidberg publicly devours an Earth flag, he is sentenced to death for his anarchic behavior. Before the sentence can be carried out, the Decapodians come to Zoidberg's aid by invading Earth, teaching the populace the true meaning of freedom.
Amy's romance with Kif takes a twist when he gets pregnant. As Amy questions her commitment Kif, he must return to his ancient, mysterious homeworld to give birth in the same muddy swamp where he was born.
Dr. Zoidberg's mysterious miracle cream gives Fry and Leela superpowers. Teaming up with Bender, they form the New Justice Team, under the respective alter egos of Captain Yesterday, Clobberella, and Super King. But Leela's new duties as a superheroine put a strain on her relationship with her parents.
The crew's attempts to de-age Professor Farnsworth result in everyone returning to their more youthful stages. While Farnsworth seeks out a way to re-age the crew, the newly-teenaged Leela takes the opportunity to experience the parental childhood she never had.
Still unable to impress Leela, Fry sadly suspects that he has no importance in life - until Nibbler takes him on a mission to prevent the brains from destroying the universe. In the process, Fry learns what really happened when he was cryogenically frozen on December 31, 1999.
A mission to collect honey from deadly space bees apparently leads to Fry's sting-induced death. Leela is wracked with remorse, until Fry visits her in her dreams. As Leela's hallucinations intensify, she begins to suspect that she might be going crazy.
Professor Farnsworth forbids the crew to look inside a mysterious box. Leela can't resist taking a peek, discovering the box to be a gateway to a parallel universe.
A $300 refund for all taxpayers results in a series of interconnected stories, following the Planet Express crew's endeavors to spend their money.
Fry is abducted by aliens, who harvest his nose as an aphrodisiac. The crew traces Fry's missing nose to Lrrr, leader of the Omicronians, who decides that Fry's "lower horn" would be a much better aphrodisiac to jump start his stagnant marriage with Ndnd.
In order to compete in the Fembot's division of the 3004 Olympics, Bender is surgically rebuilt to become a woman. Her trashy behavior catches the eye of Calculon, with whom she develops a strong and confusing celebrity relationship.
Bender is incompatible with Professor Farnsworth's new Robot 1-X, but rather than get an upgrade, Bender escapes to a desert island to start his life anew. There, he meets several other outdated robots and receives a downgrade, then leads his new comrades in a rebellion against technology.
"All My Circuits" holds an audition to replace the part of Calculon's son, and Bender lands the part. Soon, Bender's uninhibited behavior proves to be a bad influence on children, and an outraged Bender leads a protest group to get himself banned from the airwaves.
Desperate to learn how to play the holophonor in order to impress Leela, Fry swaps hands with the Robot Devil. He goes on to become a skilled holophonor player, winning Leela's heart and penning an opera about her life story, but the Robot Devil still has a trick or two up his sleeve.