Gadget has been promoted to the rank of Lieutenant and recruited by the World Organization of Mega Powers (WOMP), an elite international peacekeeping organization whose goal is to defend humankind from the world's most menacing villains. That may sound like a daunting task, but with the help of some new zany gadgets and a new set of assistants: the Gadgetinis - a team of pint-sized robotic versions of Inspector Gadget who are frequently the unintended victims of his bumbling, Gadget is still up to the task. Just like the old days, Gadget still gets help from his brainy 12-year-old niece, Penny, whether he likes it or not. Penny created the Gadgetinis two plucky teenage robots, the responsible Digit and the mischievous Fidget, to help her uncle, since Brain has now retired from active duty. Agent Fidget and Agent Digit, as Gadget likes to call them, form a comical tandem with their different personalities. Now under the control of Colonel Nozzaire, Lieutenant Gadget must battle long time nemisis Dr. Claw, along with a slew of new baddies, such as villainous mutant monsters and power-hungry space aliens. But in the end, thanks to his heart of gold, his indefatigable spirit and a little help from his brilliant niece Penny, Gadget always manages to save the day. But not without a good bit of property destruction along the way. It seems some things never change
Colonel Nozzaire is captured by aliens who think that he is Gadget. They do tests to see if he is Gadget, which he fails. Gadget tries to find him, but when he finds the aliens, he doesn't realize who they are. When the aliens trick Gadget onto boarding their ship, when find out they have a deal with Dr. Claw where they'll exchange Gadget for the moon. One of Claw's agents tells them that Gadget is really dangerous, so the aliens put a device on Gadget that will reverse his brain waves. Thinking that he is really smart, but acting stupid, they put it on him. Gadget ends up being really smart and saves the day by stopping Claw and telling the aliens that no one owns the moon, so they can live there if they want.
The Colonel is taking his first vacation in twenty years, so it's Gadget mission to protect him from any MAD agents and let him have a good time.
Dr Claw is stealing vintage aircraft either for his personal collection or to build up a private airforce. Either way Gadget has to find him and save the day. Which, thanks to Penny and the Gadgetinis, he once again manages to do.
Gadget is guarding some military vehicles that were leant to a new movie being filmed. What he doesn't know is that the Entire crew (except for the famous star) are all MAD agents, there to steal the vehicles.
WOMP intercepts a MAD transmission and learns that they have located the supposedly mythical island of Shangrilala. The waters of Shangrilala are a real fountain of youth and Dr. Claw intends to use them to make himself and his agents immortal and sell the water to dicatators who'll do his bidding for eternal youth. Gadget is sent to the island to protect it but by the time he arrives MAD has already imprisoned all the islanders, renamed it Claw Island and begun draining the waters. As always Gadget hasn't a clue anything's wrong so it's up to Penny and the Gadgetinis to make Gadget save the day again.
One of Dr Claw's MAD scientists creates a cloning machine that creates evil duplicates and plans to use it on the World Leaders meeting at a summit in Paris. Since Gadget is head of security the scientist creates a duplicate of him to abduct the world leaders so they can be copied while the real Gadget is dumped into a quicksand pit which he thinks is a spa mudbath. Penny is captured by the duplicate Gadget so it's up to Fidgit and Digit to save the day without her advice.
Dr. Claw hires two corporate headhunters to find him the ideal second-in-command and they use Halloween as cover to invite candidate criminals to a Halloween party in a trap filled house so they can be tested. Guess who stumbles into the party while trick-or-treating with Penny.
A crazy opera singer who can control bees with her voice and turn regular bees into "killer" bees uses them to rob Fort Knox then sets her sights on making Washington, DC her personal beehive. Can Lieutenant Gadget stop her? Maybe, if he ever figures out that his favourite opera singer is up to no good.
Dr. Claw tries to take over a petroleum rich country where wrestling is the national sport by planning to stage a coup when the King attends the Royal Wrestling Championship. Colonel Nozzaire (who was having a pleasant daydream about Gadget's funeral at the start of the episode) sends Gadget undercover to investigate the Championships.
The Eiffel Tower beomes the latest monument to vanish into the ground as Dr. Claw begins collecting the world's monuments. Gadget and the Gadgetinis investigate the tunnels leading from the tower and capture a teenage mutant ninja gopher (I'm kidding about the ninja part). Gadget figures the case is solved but Penny realises the gopher is young and that its even bigger mother will come looking for it.
In England people whose homes have been ransacked keep turning up wandering the streets in their nightclothes with no idea how they got there. Gadget is sent to investigate but has become sidetracked with trying to sell toystores the handcarved toy soldiers the hospitalized Colonel Nosehair has been making to relieve his stress. The toy stores aren't interested because all everyone wants is the hot new toy The Wuzzley. While Penny thinks it's cute she's noticed a connection between it and the robbery victims. Now if only she can figure out how to get her uncle to investigate.
Master of Disguise "The Chameleon" vowed to break out of jail for revenge on Colonel Nozzaire and, thanks to some inadvertant aid from Gadget, he's now free to seek vengeance.
Gadget is sent to Neutralia, the world's only source of the supermetal neutronium, to rescue King Olaf who has supposedly been kidnapped by the ghost of King Thor. It turns out that Thor seems all too real and intends to take over the country and give MAD the neutronium so Dr Claw can build an invincible army.
Gadget, Penny & the Gadgetinis travel to the small western town of "Cut N' Shoot" for the ceremony to rename the town as "Gadgetville". But when they arrive the town seems deserted because everyone's hiding. The fearsome Barker Gang is on the way and since the sheriff can't handle them they're renaming the town so Gadget will. Too bad he thinks it's all a game.
Gadget is sent to investigate Bigfoot sightings which he thinks are a hoax but will give him the chance to enjoy some camping; but there's something roaming the mountains.
CIA Agent Foxy discovers a MAD plot to use a mysterious metal from a meteor to turn people into animals just before he's turned into a fox by a MAD scientist. Foxy is teamed with Gadget to crack the case but Gadget thinks he's the Colonel's talking pet dog.
A MAD Agent posing as a genie tries to keep Colonel Nosehair (pronounced Nozzaire according to the Colonel) and Gadget occupied at an amusement park while Dr. Claw finishes building a giant sized Gadget robot to crush them both.
Dr Claw wants to get his hands on the sealed "Peace Arsenal" of the world's deadliest weapons and the key to it is in the possession of the daughter of WOMP's commanding officer. The same woman Gadget has just fallen for.
WOMP is broke so Gadget is entered into a TV survival show with a $10,000,000 grand prize. The problem is the other contestants on the island (the superstrong Mountain Momma, the slime monster Swamp Man and the feral Rat Boy) were specially recruited by MAD to destroy Gadget during the show's extreme stunts and make it look like an accident.
Colonel Nosehair decides to follow his therapist's advice about reducing his stress level and fires Gadget but Gadget thinks he's being sent undercover. After a couple of disasterous menial jobs he's hired by a Temp agency that's a front for MAD to send him to do their dirty work under the guise of doing odd jobs.
Gadget is sent to investigate why Dr. Claw is holding a contest with a $1,000,000 prize for the owner of the world's stinkiest animal. Meanwhile Penny has given the Gadgetinis experimental digestive systems so they can eat and turn the food into electricity. They quickly become addicted to eating and try everything which causes the digestive systems to overload and emit noxious odours so they win the contest. Gadget is happy to get the cheque but the problem is that the contest is a front for a MAD plot. The winning animal is to be squished and their concentrated stink extract used to arm an orbiting stink bomb which will cover the world with a foul smelling stench. Then MAD will sell the scent neutraliser their chemists created for a fortune since everyone in the world will be a customer. Since the Gadgetinis won they're taken to the squashing machine and Gadget's too happy to have won $1,000,000 to interfere so it's up to Penny to save the day.
Dr. Budd's new invention is the Imaginatron which turns thoughts into reality. It's of great interest to Dr. Claw so he arranges for the Doctor and her WOMP bodyguard Gadget to be diverted to a fake airport when she flies to Geneva to demonstrate the machine before the world science council.
Cold temperatures strike beach resorts around the world while Antarctica becomes a tropical paradise. Gadget is assigned to go to Hawaii to investigate but suddenly decided to go to the South Pole instead after seeing an infomercial by Cindi, the head of the new "Down Under Estates" condominum development. Penny investigates and finds subliminal messages in the ads which are luring in buyers and realises her uncle's heading straight into a MAD stronghold.
Two alien teenagers (technically one alien with two heads but the heads act like brothers) crash land in the desert while looking for a beach. Their arrival is detected by a hawkish General (Earth for Earthlings only!) who dispatches two crazed astronomers to gun down the aliens. Meanwhile Penny is enjoying a weekend at the beach and Colonel Nosehair dispatches Gadget to investigate reports of a UFO in the desert. Gadget picks up the hitchhiking aliens but doesn't realise anything's unusual about them and takes them to the beach with the astronomers in hot pursuit.
A MAD agent equipped with a mask of Gadget's face and retina prints plus his fingerprints and scent enters WOMP and takes the Gadgetmobile and uses it for a crime spree. Using its vacuum attachment he's able to clean out diamond exchanges and armoured cars filled with gold. Gadget is arrested and taken to prison but believes he's won WOMP's Agent of the Year award and has been sent to a vacation resort. While Colonel Nosehair is initially happy to be rid of Gadget that changes when General Sir tells him that without their only field agent the Board of MegaPowers will shut down WOMP. Meanwhile Penny and the Gadgetinis are trying to find the imposter before the other prisoners get rid of Gadget and WOMP ceases to exist.