Ghost Whisperer explores the spiritual side of life and death as Melinda navigates among the dead and the living in her sometimes chilling, sometimes heart-rending and sometimes amusing attempts to act as an intermediary between the ghosts and those they haunt. Jim, her husband, worries about the emotional toll this work is taking on his wife as they embark on a new life together.
Melinda recently has revealed her gift to her new friend, Delia Banks, a single mom who works in Melinda's antique shop. However, Melinda fears the consequences of drawing Delia into this unconventional world.
After being rescued by Jim from a fire at the Rockland University, Eli has a near death experience. Melinda becomes friends with Eli and soon discovers that they both have the same abilities.
Melinda reconnects with old high-school friends after one of their classmates dies mysteriously.
Melinda tracks down a ghost who is targeting girls on a social-networking Web site.
Melinda and Jim go away on a romantic cruise and Melinda comes into contact with an angry ghost who haunts a newlywed couple.
Melinda investigates the sudden death of a high-school athlete whose ghost is following a family that is not her own.
When a child's imaginary friend disrupts a wedding, Melinda tries to calm the ghosts causing chaos.
While facing dramatic personal changes, Melinda struggles to help a desperate teenage ghost, feeling her gift of being able to talk to the dead is no longer helpful.
Melinda tries to help a man suffering from amnesia regain his memory.
Melinda discovers the secret of a girl who has been missing for 12 years.
Melinda helps a disillusioned ghost out with marriage problems.
Melinda helps a family in turmoil after a freak accident. Meanwhile, Delia has her first haunting and discovers why sometimes it's easier to be a skeptic than a believer.
Melinda will face her greatest fear as she embarks on a road trip with Sam. Along the way, they encounter some troubling incidents.
Finding a mass grave in a local lake has caused a mass haunting over one man which Melinda must face.
Melinda must deal with the spirit of an overbearing mom who is suppressing a deep and dark secret.
Sam may discover Melinda's secret and rethinks his relationship with her after she's caught in several lies.
Melinda reveals her gift to Sam, but his reaction is not what she had expected.
Melinda and Sam's relationship hangs in the balance after Melinda shares some devastating news.
Sam has a brush with death as he risks his life to save Melinda from harm.
A young woman in Eli's apartment building is being haunted.
A ghost causes problems for a television show that is filming in the Grandview town square.
Melinda discovers that the spirits trapped in a dollhouse have other plans.
Melinda and Jim start making wedding plans and Melinda notices one of Neds from school has a ghost who thinks he's a vampire attached to her.
Jim and Melinda's wedding is overtaken by an ambitious wedding planner while Melinda deals with dreams that seem to threaten her child. Elsewhere, Eli's ex, Zoe, is caught up in a book sale with tragic consequences.