A drama centered on the personal and professional lives of five surgical interns and their supervisors.
Seattle Grace Hospital springs into action to save the lives of two young girls whose powerful story will force some of the doctors to revisit the effects of bullying on their own pasts. Meanwhile, Meredith must adjust to changes at home with her new roommates while Bailey continues to fight for the Chief of Surgery position and Jackson prepares for April’s return to Seattle.
The pressure is on as a determined Bailey tackles her first day as Chief; meanwhile, April's marriage is in jeopardy and she finds herself unable to address her problems; Meredith struggles to juggle all her responsibilities and Amelia works to define her relationship with Owen.
Maggie reevaluates her life choices after receiving an invitation to her ex-boyfriend’s wedding; Richard questions Bailey’s loyalty, and Jo confides in Stephanie about a secret she’s been keeping from Alex. Meanwhile, Alex struggles with making a difficult decision that will affect the lives of newborn twins.
Owen suggests the interns learn a vital lesson on how to break bad news to patients’ families, and Arizona’s 90-year-old patient reassures her that she’s destined to find love again. Meanwhile, the sisters completely forget about the dinner party they’re hosting for everyone.
In the midst of the sisters’ dinner party, Maggie ditches her cooking duties to rush to the hospital. Meanwhile, April steps in to help cook as an attempt to avoid Jackson, and Arizona nervously waits to find out more about Callie’s new girlfriend.
Grey Sloan Memorial not only welcomes a new transfer resident, but also a patient who's the topic of converstation after accidentally sending his sex tape to his entire congregation. Meanwhile, Richard wrestles with how to progress his relationship with Maggie when an old friend visits the hospital, and April brings in a case of a young boy from the Middle-East.
The team of doctors work on a high stakes case of a long time patient, adding additional pressure to an already tense environment. Meanwhile Bailey wants Ben to kick out their new roommate, and Arizona is eager to get back into the dating world with a new wingman.
As the rumor mill around the hospital continues to spiral out of control, Grey Sloan Memorial is flooded with injured firefighters from a nearby wildfire. Maggie struggles to keep things with Andrew professional at work; meanwhile, Jo questions Alex’s priorities.
Meredith is brutally attacked by a patient, and Penny is the one who discovers her. The doctors of Grey Sloan Memorial rush to stabilize Meredith and remain by her side in the harrowing aftermath.
As the hospital deals with Meredith's trauma, Callie and Maggie perform a risky, experimental surgery on Alex's 15-year-old patient against his professional opinion. Meanwhile, Owen and Nathan are still at odds with each other, and Maggie and Andrew's relationship continues to develop.
The evolution of April and Jackson's relationship is revealed through a series of flashbacks dating back to when they first met. Simultaneously, we follow the years-long progress of one of Jackson's patients.
A patient from Meredith's very first surgery as an Intern is readmitted to Grey Sloan Memorial with a new aneurysm, and Amelia takes her case. Meanwhile, Maggie suspects that Richard knows about her relationship with Andrew, and Arizona debates dating again.
Meredith, Bailey, Jackson, Callie and Jo travel to a military hospital to perform an extraordinary and extremely risky surgery on a veteran with an advanced tumor. Meanwhile back at Grey Sloan, Andrew is tired of being Maggie’s worst kept secret; Ben makes an impulsive surgical decision; and a team of cheerleaders wreak havoc in the ER.
Richard throws everyone for a loop when he switches the resident and attending pairings, and Arizona takes a huge risk on a woman who is pregnant with quadruplets. Meanwhile, April is faced with a difficult decision.
Jackson learns about April’s pregnancy, while Alex and the team of doctors handles an hours-long triple-organ transplant surgery. Meredith considers dating again, and Andrew insists on not receiving special treatment after he and Maggie go public.
Meredith regrets taking a step forward with Will; Maggie feels disconnected from Andrew; Amelia takes another look at her relationship with Owen; Catherine shakes things up for April and Jackson.
Meredith goes on an ambulance ride with Owen and Nathan to pick up a heart for a transplant patient. Musician & MS patient Kyle Diaz is admitted to Grey Sloan Memorial with a tremor in his hand, and the residents apply for the Preminger Grant. Meanwhile, Catherine continues to insert herself into Jackson and April's business against Richard's wishes.
After a missing child forces the hospital into lockdown, Ben decides to operate on a pregnant mother without the proper surgical equipment. Miranda, as Chief, is faced with the repercussions of the event and whether or not Ben's impulsive actions were justified.
Miranda continues to deal with the aftermath of Ben's reckless decision and forms an advisory committee to recommend proper disciplinary action against him. Meanwhile, April and Jackson try to put their differences aside for the sake of their baby, and Arizona makes a decision that could affect her relationship with Callie forever.
The doctors work frantically to save a young boy who was accidentally shot. Meanwhile, Arizona is upset when Callie tries to make an important decision about Sofia’s future without consulting her
Stephanie’s relationship with Kyle becomes complicated. Meanwhile, Meredith encourages Amelia and Owen to take a chance and choose to be a real couple. Arizona and Callie are at odds and put their friends in the middle of an uncomfortable situation.
Callie and Arizona are at odds over Sofia’s future, and Stephanie questions the status of her relationship with Kyle. Meanwhile, Alex and April work on a pregnant teen that is readmitted to Grey Sloan Memorial.
Owen and Amelia take their relationship to the next level; Alex gains some clarity on his future with Jo; and Callie and Arizona continue to struggle with the current custody arrangement.
Meredith and Maggie support Amelia on an important day; Jo reveals that she has been keeping secrets from Alex while Arizona and Callie deal with the impact of their custody arrangement. Meanwhile, Ben leaps into action to help a friend.