Marshal Matt Dillon keeps the peace in the rough and tumble Dodge City.
Matt is summoned to help an old friend, Ab Butler, who has been shot in the back and left for dead. However, Matt faces a difficult situation when Ab's partner shows up and tells his side of the story.
German immigrant and town blacksmith, Emil Wolhter and his German mail order bride, Gretchen Mueller, are to be married. Matt, Doc and Chester along with Emil meet Gretchen at the stage station. Emil and Gretchen throw a big wedding party for all their friends in Dodge; however, not everyone in Dodge is friendly to Emil and Gretchen. Town troublemaker Tolman has it in for Emil because Tolman thinks that Emil cheated him in a blacksmith deal. Tolman and his gang scheme up a plan to get Emil Wolhter out of his house. While Emil is out of his house one evening, Tolman and his gang of troublemakers burn Emil's house to the ground. When Matt offers to help Emil find the men who did this, Emil rejects Matt's offer and pursues these men by himself. Emil administers his own brand of justice to the men.
Matt arrests Finn Pickett after recognizing his face from a wanted poster. On the way back to Dodge, Pickett's vengeful sons try to free their father as Matt and Chester face a water shortage.
Martin Nagel is a hard working store owner that has plans to build up his business and eventually leave the business to his son, Lee Nagel. When Martin Nagel is killed in a freak accident, Lee Nagel thinks that his Uncle (Hutch) did the killing. Lee is highly suspicious of his Uncle Hutch and attempts to convince Marshall Dillon that his Uncle killed his Father to claim the family business.
While Matt and Chester are transporting a prisoner on a stage coach to Wichita, Matt learns that the stage is also carrying gold. Matt fears that outlaws might attack the stage for the gold. While at a stagecoach stopover, the outlaws attack the station. Matt, Chester, the stagecoach driver along with a traveling preacher and a young woman, attempt to fight off the outlaws the best they can.
Dillon heads to Dodge to get a new man to replace the brutal, corrupt sheriff of Tascosa, with hired killers in pursuit who are unaware that the sheriff's ex-girlfriend has joined up with Dillon.
Matt's old friend, Esteban Garcia, tracks a man into Dodge and plans to kill him for stealing his wife.
Murders follow when a buffalo hunter and his browbeaten partner come to town.
Matt is taken prisoner by a madman named Rack and his simpleton partner, Augie. Matt's only hope is to turn Augie against Rack.
A young army drummer named Raffie is terrorized by two bullying mule skinners.
A row with his boss makes Ben quit his job. He leaves but says goodbye to Jake's daughter first. When he takes a horse for lost wages, Jake swears he'll kill him. The tables are turned when a hard and fast rule of Jake's soon backfires.
The vicious Dolan brothers move in on a tough cattle rancher and his non-violent son.
A man brings his dead friend into Dodge to give him a proper wake.
A young drifter takes a job as cook at Delmonico's but accidentally kills a crazy buffalo hunter who complains about his cooking.
A scheming woman (Else Hedgepath), who is after the money and wealth of Hannibal Bass, makes a play for Hannibal, but runs into some serious, SERIOUS trouble though when she tangles with *MRS* Bass!
In a family that believes in taking care of its own--including administering punishment within the family for crime--one of two grown brothers appears to have committed murder, but which one?
A man shoots his partner, flees, and is caught by two men claiming to be lawmen.
When 2 outlaws shoot and kill a storekeeper and his young employee, Matt sets out on to the prairie to find the killers. When one of the killers (Red Lime) dies from a gunshot wound from Marshall Dillon's gun, the other outlaw (Joe Lime) vows revenge on Matt Dillon for killing his Brother When Matt returns back to Dodge without the men and with a fever, Doc gives Matt something to help him rest and fight the fever. While Matt is resting, Chester cleans Matt's gun. Chester removes all of the bullets from the chambers, but before Chester can put the bullets back into Matt's gun, Chester gets a message that Doc wants to see Chester in the Doctor's office While Chester is up in Doc's office, the other killer rides back into Dodge wanting revenge for Matt killing his Brother. He tells Carl the stable man that he plans to kill Matt. Carl the stable man tells Miss Kitty that the outlaw Joe Lime was now in Dodge and is gunning for Matt. Miss Kitty awakens Matt from a state of fever to warn.
A man and his wife come across a lone trapper and make camp with him. Next day, the husband comes to Dodge to report to Doc that his wife is sick, but Doc finds the woman beaten to death, and the husband accuses the trapper.
The theft of a sack of potatoes leads to increasingly violent hostilities between the Scooper and Galloway families.
Matt rescues teen-aged Trudy Trent from a life of isolated poverty with her incestuous and alcoholic father, but he subsequently learns that "Hell hath no fury like a woman scorned" when he rejects her misguided romantic overtures toward him.
Dillon goes after cowboy Jake Bayloe after he guns down his partner in the Long Branch , shooting Kitty in the crossfire and critically wounding her.
While Chester is out searching for Doc, his horse is injured. Chester goes to a house for help and is instead taken prisoner.
After witnessing the callous murder of her kindly father, Harriet Horne disregards Matt's advice and unwisely attempts to extract revenge from the perpetrators by making them jealous rivals for her attention.
A concealed gunman takes a shot at Chester, and it may have been a bank robber, or it may have been someone who's been making trouble at the Long Branch.
Hot-headed Tom's new wife used to be a river-boat girl, and when a gunman from her old life recognizes her, a battle between the two men is brewing.
To protect Kitty, Matt is forced to physically (and publicly) subdue fractious troublemaker Pat Swarner. When Swarner is subsequently found murdered, oft-inebriated Jud Sloan's claim that the Marshal was the killer seems uncomfortably credible.
Marshal Dillon must find a suitable home for Charity Gill, a young orphan, after the little girl's father dies when his cabin catches fire. Charity insists that she should live with the Dodge City lawman.
Horse thieves murder a man to get his animals. Matt tracks the criminals to a Kiowa camp.
Rough and rowdy Minnie comes to Dodge Cith and sets her designs on Doc Adams much to the delight of Matt, Chester and Kitty. Trouble comes though when Minnie's husband comes to Dodge and finds out that his Minnie is sweet on Doc.
Vengeful former convict Nate Bush sets off a tragic series of events when he informs Matt that well-liked new arrival Cole Treadwell is actually Cole Trankin, an escapee from the Arizona Territorial Prison.
A gunrunner supplies the Pawnee with weapons. Matt arrests him, but when the Pawnee find out, they capture Matt and free his prisoner.
Hot tempered Andy Coe and his wife want to sell their wagon to Moss, but can't when Ed Fallon's team spooks and crashes into their wagon. Fallon pays for the broken wagon and gives Andy a job. Fallon is sweet on Andy's wife.
A man claiming to be a sheriff from Texas comes to Dodge and asks Matt for help tracking down a named fugitive, but the man may not be a sheriff.
A pretty girl arrives in town and chases Chester, who's happy for her to do so, but the young woman has a secret that may land her in jail.
When an ex-marshal passing through town is shot in the back, Matt suspects a new saloon gal might have had something to do with it.
When Roy Tayloe is murdered following a poker game, quick-tempered Harry Miles is certain that daughter Melinda's suitor Tom Potter is the killer. Miles quickly becomes impatient with Matt's methodical investigation of the crime and threatens to kill Potter himself unless he stays away from Melinda.
Matt and Chester find Rod Ellison shot and paralyzed on the prairie and return him to Dodge for surgery. Ben Witter abrasively advises Matt that he is a deputy sheriff from Pueblo who has come to Dodge to arrest Ellison for robbery, but Matt is suspicious of Witter's refusal to produce a valid arrest warrant.