House will do whatever it takes to solve a case before it's too late, from sending one of his team to break into a patient's home in search of clues, to attempting a controversial, trial-and-error form of treatment to see how a patient responds. House's methods may be suspect, but his results are not — he saves lives no one else can. Always in House's way is Dr. Lisa Cuddy, the Dean of Medicine and hospital administrator — and ethical gatekeeper of the hospital who is in constant conflict with House over his extreme treatments and unconventional behavior. House's former love Stacy Warner recently accepted a job as General Counsel to the hospital, and her presence there has reignited feelings House thought were safely buried.
A death row inmate is felled by an unknown disease and House decides to take on the case, over Cuddy and Foreman's objections. House also has to deal with Stacy who is working closely with him, while Cameron has to cope with a dying patient.
Dr. Wilson convinces House to take the case of one of his patients, a young girl with terminal cancer who starts suffering from hallucinations.
An asthmatic man suddenly becomes unconscious and falls off of Dr. Cuddy's roof while working on her house.
While in Africa, a famous doctor becomes inexplicably ill and is sent to Dr. House for treatment.
A Princeton student who is graduating suffers a seizure while partying at a frat house. House's parents also drop by to see their son.
A professional bicyclist is brought in after collapsing during a race, but House doesn't want to treat him because he thinks the athlete is taking performance-enhancing drugs. House only becomes interested when the patient admits to taking the drugs.
A gay man with full-blown AIDS collapses in front of House's home and goes into shock. When House discovers the man's father is suffering from symptoms of his own, he must determine if they might be connected and save both their lives. Meanwhile, Cameron faces a potentially life-threatening disease of her own.
House and Chase find themselves in a serious situation after a young mother with stomach pains dies. Months later, Stacy counsels Chase prior to his disciplinary hearing, and must determine whether Chase made a mistake that ultimately led to the patient's death. She soon realizes he is holding something back.
With Foreman as House's supervisor, the team must figure out if a woman who cried wolf too many times is really ill.
While attending his editor's retirement party, a journalist collapses and hits his head on a desk. When he regains consciousness, his sentences are garbled and incoherent, so he is rushed to Princeton Plainsboro Teaching Hospital. With House and Stacy stranded at an airport due to bad weather, the team is forced to solve the case with House helping out over the phone.
While House's staff tries to diagnose a woman whose uncontrollable muscle flailing caused her to crash her car, House and Stacy try to resolve their relationship issues once and for all. Cameron refuses to take her HIV test, wary of the results.
While a severely burned teenager is admitted and his blood tests come back with strange results, House makes himself the guinea pig in his own unofficial tests of a new drug designed to treat migraines to prove a former medical school colleague is wrong about the drug.
House uncovers a startling secret when he treats a teenage supermodel for heroin addiction. Meanwhile, Wilson hopes the increased leg pain in House's leg is an indication his leg nerves are regenerating.
House takes the case of a man who experienced a seizure but wasn't aware it happened. When the man suffers a heart attack and needs a heart transplant, the team races to diagnose a dead woman's illness so they can harvest her heart to save their living patient.
House believes a woman is trying to kill her husband and tries to find the proof to confirm his suspicions. When Wilson moves in with House after separating from his wife, he learns Wilson is a great cook.
Melinda, a troubled teenage girl who is immuno-compromised as a result of the medications she must take after a heart transplant, has a severe allergic reaction and goes into shock when her boyfriend visits her. Meanwhile, House and Wilson continue to work out the problems in their new living arrangement.
When a six-year-old boy is brought in with the same symptoms as another patient who died years ago under House's care, House believes the cases are identical and he can predict the course of the boy's illness. Meanwhile, the clinic hosts a poker night to benefit the oncology department.
House has to work fast when a woman comes in with a life-threatening case of insomnia. Meanwhile Cameron is angry at Foreman for stealing an article she worked on.
House treats a 15 year old faith healer, while Wilson feels left out when he finds out House has a weekly poker game.
When a police officer with a gunshot wound to the head and uncontrollable laughter is admitted, House and the team are baffled. When Foreman begins showing the same symptoms, they race to determine the cause of the illness before Foreman's condition takes the same path.
Foreman continues to experience the same progression of symptoms as the police officer. When he realizes he may be facing imminent death, he calls his father who comes to his son's side. As it comes down to a race against time, House believes the solution to the illness is in the police officer's apartment.
A young mother has a seizure while bathing her newborn son and nearly drowns him. House and the team have two cases at one time as they try to save the infant and determine the cause of the mother's seizures.
A 16-year-old Hurricane Katrina victim suffering from hallucinations as a result of the tragedy is brought to House by his former bandmate who recently found out the girl is his daughter. Although House fears his friend is being scammed, he takes the case. As he works his way through the girl's lies so he can diagnose and treat her, he's forced to tell a few lies of his own.
As House and his team are working on the diagnosis of a man with a giant, swollen tongue, the husband of a former patient walks into House's office and shoots him. House continues to treat his patient from his ICU hospital bed with the shooter, who has been shot by hospital security and hand-cuffed to his bed, as his roommate. When the after-effects of the shooting begin to impact House, he starts to question his own ability to diagnose properly. As his patient's body deteriorates, House struggles through his self-doubt and must trust his team to find a way to solve the case.