Family Macahan's is the story of the white man's conquest of the American West, which we follow through family Macahan valiant struggle for survival. It is the story of mountain men who went west to explore the world beyond the next river bend, the fur trappers who nearly extinct buffalo herds, the gold graves searching for El Dorado, about peasants who became wealthy landowners and the simple people who were on the run. There is also a story about the American Indians. Brave and fearless, but hopelessly outnumbered, these primitive people were the ultimate losers in the battle for land in the west.
Rancher Henry Coe hires a professional gunman to drive the Macahans off what he considers to be his property. Frank Grayson ingratiates himself with the Macahans, but Josh recognizes him as the gunman once hired to kill Luke.
Jessie is blindly in love with a handsome young stranger named Bob, who rescues her from a nasty villain. Together they flee to a small town and finds a priest who agrees to perform the ceremony.
A by-the-book Army lieutenant clashes with the Macahans when he hunts for an Indian chief suspected of raiding wagon trains.
Josh is friends with Cora Johnson and her children, who are operators of a ferry service. In this way he becomes embroiled in a dispute over ferry operations, and the conflict takes an unpleasant turn when capital borrowings by Cora's retarded son is accused of murder.
Luke embarks on a double mission: to win back his old flame Hillary and find the man who is suspected of murder as Luke once accused of - and to get him to confess.
Zeb Macahan is asked by general Sheridan to find Louis Riel so he can be sent back to Canada since he is wanted.
The Macahans are out on a riverboat when the boat is attacked by river pirats.
Army surveyors led by Luke Macahon is ambushed and shot at in the mountains by an unknown person.
Luke Macahan finds out that there is still a $5000 reward on his head, and to expect more and more bounty hunters as an effect off that fact.