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Being the son of a concubine, Jun is mistreated by his older half-brother and dismissed from his father's birthday feast. Jun dreams of being a great general that fights barbarians, just like his father.
Everyone frantically searches for Jun as he was left out in the bitter cold as punishment by Seok. Jun gets saved by an ex-royal physician and meets his young daughter, Mi-hyeon.
Jun and Mi-hyeon are captured by the barbarians and about to be sold as slaves. The barbarians propose a trade to General Heo but he is forced by the Lordship to decline it.
Jun has now dipped into illegal trading of medicinal ingredients. His position as a concubine's son continues to haunt him in the present.
While the officers are in search for Lee Jeong-chan and his daughter, Da-hee, he passes away. Heojun decides to conduct illegal trade to leave Yongcheon and help Da-hee escape.
Jun gets caught for illegal trading and his father is forced to punish him. Since Jun handled Lee Jeong-chan's funeral, he gets interrogated on the whereabouts of Lady Da-hee.
After Jun's father secretly releases him, he attempts to leave Euiju with his mother and Da-hee. They arrive near the capital at Samgae port, which seems to have a tense atmosphere.
A crook named Gu Il-seo promises to get Jun an ID but gambles his money away instead. Jun's mother suddenly becomes sick so they take her to Doctor Yu, a renowned physician in the village.
Heo Jun starts to work for Doctor Yu to learn medicine. He meets Ye-jin again at the dock...
Jun is scolded for bringing the wrong type of water for medical use. He is determined to become a doctor and diligently memorizes the herb names.
Jun gets accused for stealing medicine from the storeroom and tries to find the culprit. Jun's mother searches for work and gets introduced to Doctor Yu's wife.
The priest teaches Do-ji that the most important part about being a doctor is to have sympathy for sick people. Heojun receives an identification to go to Hanyang.
Doctor Yang's people made Do-ji fail the exam because of his family background. The same thing happened to his father, and he challenged Doctor Yang to the Nine Needles Contest.
Doctor Yu beats Doctor Yang in the nine needles competition. Meanwhile, Yang Tae is looking for Heo Jun...
After much anticipation, Do-ji returns and seems to be devastated after taking the exam. Jun is now given permission to collect herbs with the other men.
Jun gets tricked by the herb collectors and is nowhere to be found. Lady Da-hee is ill from disappointment and stress but still searches for Jun.
Heojun gets married to Da-hee despite their status. Do-ji burns all his books after he failed the exam.
Da-hee is adjusting to her new lifestyle, however Jun's mother is in shock when she talks back to Do-ji's mother. Heojun studies medicine with Ye-jin.
Heojun moves into his new place. He gets misunderstood by Do-ji as a patient tries to bribe him.
Master Do-ji is rumored to have caught Jun accepting bribes from the patients. Jun persistently begs Doctor Ahn to teach him about medicine.
Jun is determined and diligently learns about medicine from Doctor Ahn. Ye-jin makes the decision to follow Master Samjuk and help him treat lepers.
Do-ji loses a patient because Doctor Yun's physicians did not take Heojun's advice. Heojun tries to save Seonduk who tried to commit suicide.
Heojun saves Seonduk's life. He gets in trouble by Doctor Yu and his people for treating patients at his house.
Doctor Yu promotes Heojun to be the store keeper. Bu-san-po gets mad and tries to attack Doctor Yu.
Lady Da-hee is accused for stealing silk. As Jun's mother and wife are suffering in starvation, Jun decides to quit working at Doctor Yu's clinic.
Lord Sung In-chul asks Doctor Yu to treat his wife who is deathly ill. Doctor Yu decides to send Jun, instead of Do-ji, to treat the Lord's wife.
Lord Sung In-chul believes that Jun's acupuncture treatment went wrong and locks him up. However, Jun is determined to cure his patient by all means.
Heojun cures Lady Sim and returns home. He gets a letter of recommendation from Lord Sung to become a royal physician.
Doctor Yu burns Heojun's letter of recommendation from Lord Sung and kicks him out of the clinic. They also take the gifts he received from Lady Sim.
Jun becomes a reckless drunkard after getting kicked out of Doctor Yu's clinic. Il-seo is ecstatic when he finds out that his wife is pregnant.
Bu-san-po reunites with Heo Jun only to pull him into a plot that may endanger their medical careers.
Heo-Jun renews his will to pursue medicine, but quickly finds that it won't be an easy way back.
Heo Jun follows Master Samjuk to Samjuk Temple and learns to treat lepers.
Heo Jun finds out about Master Samjuk's past and gets an unexpected visitor.
Sang-hwa and Su-yeon leave Samjuk Temple and quickly realize the harsh reality of the outside world.
Heo Jun leaves Samjuk Temple and heads toward Hanyang to take the state medical exam.
The state medical exam draws dangerously near as Heo Jun decides to help a family in need.
Heo Jun must leave for Hanyang, but the sick patients he comes across continue to delay him.
Heo Jun finally leaves for Hanyang, but does not know if he can make it in time for his exam.
Do-ji passes the state medical exam and proudly comes back to Saneum, but Heo Jun is no where to be found.
Rumors about Heo Jun's feats in Jincheon reach Saneum as Heo Jun comes back home. Meanwhile, Do-ji leaves for Hanyang to become a royal physician.
Doctor Yu and Heo Jun reunite while Do-ji begins his training in Hanyang.
Heo Jun treats patients at the clinic as Doctor Yu's student and receives an unexpected visit from Dol-swe. Meanwhile Do-ji comes across challenges of his own at the royal palace.
Dol-swe prevents other patients from being treated until Heo Jun cures his mother's blindness.
Heo Jun goes against Doctor Yu's orders and treats Dol-swe's mother using his own method. Do-ji sends a letter to Ye-jin.
There is a plague epidemic that starts in Dushi-gol. Doctor Yu and Master Samjuk go to treat infected patients, but Heo Jun is ordered to stay at the clinic.
Heo Jun refuses to leave Doctor Yu and Master Samjuk by themselves to treat patients of the epidemic. Do-ji finishes his training and has his rank and post announced.
Heo Jun finds out about Doctor Yu's illness and is determined to find a cure. Ye-ji leaves the clinic to go to Do-ji.
Heo Jun and Master Samjuk continue their efforts in finding a cure for Doctor Yu. Lady Oh tries to prevent Ye-jin from meeting Do-ji as he prepares to get married.
Do-ji finds out that Ye-jin is in Hanyang. Master Yu mysteriously demands that Heo Jun and Master Samjuk meet him in faraway Milyang.
Heo Jun delivers the news of Master Yu's death to Lady Oh and Do-ji. Heo Jun takes over the clinic when Lady Oh decides to pay a visit.
Do-ji gives Lady Kong-bin the wrong tonic by mistake. Heo Jun opens a clinic in Saneum after seeing poor patients who are unable to receive treatment at Doctor Yu's.
Heo Jun and Oh-keun go to Hanyang to take the state medical exam.
Heo Jun passes the state medical exam with highest honors, causing Do-ji to worry about his status in the medical bureau.
Heo Jun and his family move into their new home in Hanyang. Heo Jun is late on his first day of work due to Da-hee's miscarriage.
Heo Jun continues to exhibit outstanding knowledge during his training, causing Do-ji to further worry about his standing at the bureau. Ye-jin enters the palace to become a royal nurse, but finds herself a shocking welcome.
Heo Jun reunites with Oh-keun and sees the horrible conditions of the public hospital. Do-ji gets another promotion and Ye-jin begins to see the non-medical duties required of her as a royal nurse.
Heo Jun gets in trouble with the senior doctors for not listening to their instructions. Ye-jin finds that the prisoner Lady Yun is pregnant.
Heo Jun reunites with Ye-jin and tells her of how Doctor Yu died. Heo Jun reaches the end of his training and is about to find out his rank and post.
Heo Jun is posted to work at the public hospital despite his excellent grades. Ye-jin and Chae-sun get in trouble for missing medicine from their storage.
Heo Jun proves the innocence of Ye-jin and Chae-sun. Do-ji finds Ye-jin working at the public hospital.
Do-ji tries to have Ye-jin transferred from the public hospital. Heo Jun discovers corruption and tries to fix the problems.
Heo Jun must recite the Physician's Creed a thousand times, a feat no person has ever accomplished before.
Heo Jun finishes reciting the Physician's Creed a thousand times and moves Doctor Yang. Lady Kong-bin goes into early labor, putting Do-ji in a difficult position.
Do-ji asks for Hong-choon's help in saving Lady Kong-bin and her baby. Heo Jun treats an impetigo patient at the risk of his own health.
Heo Jun gets infected while treating his impetigo patient. Ye-jin is forced to attend a banquet where she learns what a "medicine courtesan" is.
Lord Jung-myung confesses his feelings to Ye-jin. Meanwhile, Heo Jun finds himself in a bind when a man hangs himself in the tonic room.
Heo Jun finds suspicions of murder. The nurses take an important exam to determine their fate.
Heo Jun finds another case of possible murder and is asked by Lord Jung-myung for his help in finding the suspect.
Heo Jun goes undercover as a smuggler to find out where the poison used to kill the Fifth Counselor came from.
Heo Jun finds out who ordered the murders of the Fifth Counselor and Assistant Park. Lord Jung-myung is arrested and accused of treason.
Heojun is desperate to see Lord Lee before anything dire happens. Jang Swe and Yong Dal meet with the other men for drinks.
Yang-tae goes to Doctor Heo's mother and wife for assistance. A new overseer is introduced to the nurses and doctors at the bureau.
Do-ji treats Lady Kong-bin's brother-in-law, but his illness relapses. Meanwhile Heo Jun treats a patient with the same illness at the public hospital.
Heo Jun is ordered to replace Do-ji in treating Lady Kong-bin's brother, but his methods directly challenge the medical skills of Doctor Yang.
Heo Jun tries to treat Lady Kong-bin's brother, but is given a hard time when the man refuses to drink his tonic.
Heo Jun tells Do-ji that Lady Kong-bin's brother has gastric cancer, but Do-ji asks Jun to keep it a secret.
Heo Jun promises the king and Lady Kong-bin that he will cure her brother's cancer in five days.
Heo Jun's five days of treating Lady Kong-bin's brother are up and the fate of whether he can keep his hand is decided.
Heo Jun is sentenced to lose his hand for being unable to cure Lady Kong-bin's brother. Ye-jin and Heo Jun's fellow colleagues plead for his pardon.
Heo Jun not only keeps his hand, but is also handsomely rewarded for curing Lady Kong-bin's brother. Do-ji feels threatened at Heo Jun's success.
So-hyun performs acupuncture on a patient when it is forbidden for nurses. Do-ji finds himself in a tight spot because of his relationship with the nurse Sae-hee.
The scandal between Doctor Yu and Sae-hee has spread all over the palace. Heojun receives a surprising praise from Doctor Yang.
Do-ji is sent abroad with an envoy mission to China as punishment. Lady Oh is seriously ill, but refuses treatment from Heo Jun.
Heo Jun treats Lady Oh's illness in secret. Chinese envoys are on their way to Hanyang and the public health nurses are expected to entertain them.
Lady Oh finds out that Heo Jun had been treating her without her knowledge. Ye-jin and So-hyun are chosen to entertain the Chinese envoys.
So-hyun and Ye-jin are being prepped to entertain the Chinese envoys. Heo Jun tries his best efforts to save Ye-jin.
Ye-jin and So-hyun have an unexpected turn of events when one of the Chinese envoys begins to have stomach pains. Doctor Heo is called to attend to the king on his hunting trip.
The new constabulary deputy recognizes Heo Jun from his days in Yongcheon and starts an investigation on his past.
Royal Physicians and Nurses including Heo Jun and Ye-jin are sent out to Hwanghae Province where a plague has broken out.
The constabulary deputy gives Heo Jun time to treat patients that were infected by the plague. Heo Jun runs into an old acquaintance.
Doctor Heo finds Dol-swe locked up with terminally ill prisoners and has them released to get treated. Doctor Do-ji returns from his expedition from China.
Chae-sun becomes infected with the plague. Doctor Heo, as well as the other doctors try different curing methods in hopes to find the cure for the plague.
Heo Jun and everyone else who helped treat the plague are handsomely rewarded by the King. However, Heo Jun's past prevents him from enjoying it.
Heo Jun's past is quickly revealed to the others as he and Da-hee get arrested by the constabulary deputy.
Heo Jun's allies try to find a way for him to be pardoned for his crimes, but the people at the Office of Grand-Censors protest against it.
Heo Jun is told of his sentence from the constabulary deputy and is given a chance to see Da-hee for one last time. Meanwhile, Lady Kong-bin becomes severely ill.
Lady Kong-bin awakens and begins to feel much better. Doctor Heo's ultimate fate is still undecided between the King and his officials.
Heo Jun is granted amnesty from the King for his past crimes. Do-ji becomes Lady In-bin's personal physician after she is found to be pregnant.
Do-ji makes sure that Lady In-bin gets top quality ingredients for her tonic, but it causes a shortage to make Lady Kong-bin's medicine. Oh-keun proposes marriage to Hong-choon.
Because of her growing heartache, Lady Kong-bin continues to suffer. Meanwhile, Do-ji decides to follow his ambitions.
As Lady Kong-bin's illness worsens, Doctor Heo sets off to find different herbs that may cure her. Meanwhile, Hong-choon and her husband seem to be having personal issues.
Heo Jun and his friends find out about Lady In-bin's plot and search for her hired shaman. Lady Oh seeks to make amends with Heo Jun before she leaves Hanyang.
Lady Kong-bin is in critical condition. Heo Jun decides to take a leave of absence from the palace to walk the path of a true doctor.
17 years pass and Heo Jun continues his medical research at the Royal Palace. Do-ji starts to get uneasy when Prince Sinsong's illness does not get better.
Do-ji puts Heo Jun in charge of treating Prince Sinsong's illness. Heo Jun's friends and family find out that Dol-swe is treating patients under the false pretense of being a doctor.
After realizing that it will take more than herbs and acupuncture to cure Prince Sinsong, Heo Jun finds a rather unconventional form of treatment that catches everyone off guard.
Heo Jun's treatment of Prince Sinsong proves to be effective and the King wants to reward him with a great promotion. This causes a great commotion among the ministers and other royal physicians.
A Japanese Invasion has begun and as they get closer to the capital, the court officials decide that it is time to choose who their next Crown Prince will be.
The Japanese troops are getting closer resulting in an evacuation of the capital. Doctor Heo's family awaits for him so that they may leave together.
Kyeom and the rest of the family believe that Doctor Heo has already left and decide to leave on their own. Doctor Heo, along with the other nurses and doctors, try to catch up with the King.
Heo Jun and his group are unable to catch up to the King in Kaesong. They decide to take an alternate route to meet the King in Pyongyang, when they meet with enemy troops.
Sang-hwa is shot and gets separated from the rest of the group. Meanwhile the King's counsel debates whether they should move the King to the Ming.
Heo Jun rejoins his family and the King, but no one understands why he went back for the medical texts. The King leaves for Eui-ju, but tells Heo Jun to stay behind with Prince Kwang-hae.
As the Japanese troops continue to attack, Kyeom and the others assist the soldiers in the fight. Prince Sinsong becomes severely ill after they arrive at their new palace.
The King falls ill after seeing the death of Prince Sinsong, so Doctor Heo is ordered to oversee the King. While fighting the enemy, Kyeom is injured.
The Ming send troops to help fight against the Japanese army. Heo Jun requests permission to write a new medical text from the King.
Heo Jun is the first doctor to be promoted to the rank of a minister, but a scandal that questions his relationship with Ye-jin may get in the way.
The selection process for a new queen begins and the doctors must examine each candidate. Do-ji is put in charge, but is approached by Lady In-bin's brother.
The selection process for the new queen has been narrowed down to two candidates. Jang-swe and Yeong-dal convince the others to invest money in one of the candidates.
Doctor Heo asks the King permission to leave the palace to gather medicinal information from the Ming. While he is away, Do-ji is put in charge of the King and the Queen's health.
A physician from the Ming gets placed in charge of taking care of the Queen's pregnancy. Heo Jun comes back to the palace, but shows concern after seeing the Queen's patient records.
Times passes and a legitimate prince is borne by the new Queen. Some of the court ministers start thinking of a plot to remove Prince Kwang-hae as Crown Prince.
The court ministers split sides between Prince Kwang-hae and Prince Yeong-chang with Heo Jun caught in the middle. Lack of funding prevents Heo Jun's medical compilation from continuing.
The Crown Prince, Kwanghae becomes severely ill from malaria. Doctor Heo uses a very toxic poison as a cure that causes the officials to be suspicious of his intentions.
News has spread over Doctor Heo administrating poison as an antitoxin. On-nyeon and her parents continue their efforts of helping On-nyeon's husband get into the royal pharmacy.
The King's deteriorating health causes the ministers to divide over who should be the next King. Heo Jun is in danger of taking full responsibility if the King dies.
The King regains consciousness and names who will be the next in line to the throne. Heo Jun's mother is beginning to show signs of senility.
Some of the ministers attempt to get Prince Yeong-chang placed as the next King despite the King's original edict. Heo Jun prepares to face punishment after the King passes away.
Heo Jun's fate is decided when the King decides to banish him for the capital. Doctor Heo's mother begins to have signs of dementia.
Heo Jun is banished, but the villagers around him hear of his medical skills and seek him for treatment. Haman and On-nyeon try to end their husbands' gambling problems for good.
Do-ji decides that the compilation cannot be finished without Heo Jun's help and requests his help. The Magistrate gets word of suspicious activity around Heo Jun.
After Doctor Heo is released from exile, the King asks him to return as a palace doctor. Jun reunites with his wife and mother.
Doctor Heo and his family get settled in at their new home in Saneum. The Exemplar had been illegally copied and sold to people in the capital causing chaos.
Heo Jun alerts the Royal Palace that a plague has broken out. Heo Jun asks the magistrate to open the granary stores for the starving villagers, but is refused.
