Professor Layton's daughter, Katrielle Layton, runs the Layton Detective Agency together with the talking dog Sherl and her assistant Ernest, and solves strange cases that happen everyday in London. Originally, she started the job with the purpose of finding her father, Hershel Layton, who had disappeared suddenly, but her incredible ability to solve puzzles made her well-known and she receives numerous requests.
Katrielle Layton, an intrepid investigator who heads up the three strong team at the Layton Detective Agency alongside her assistants Ernest and Sherl, takes on a case involving a mysterious house in which a new tenant's family suddenly and inexplicably disappeared.
Katrielle is approached by Pastel, a struggling musician, who claims that a strange dress he bought for his wife Olivia is causing her to become possessed.
A young woman named Liv seeks Katrielle's help after she is visited by her late husband, Andy, apparently returned to life as a zombie.
Inspector Hastings enlists the Agency's assistance in tracking down a serial jewel thief before the criminal can enact their most daring heist yet.
The team becomes involved in a new case when a young man approaches the Agency in the hope of discovering a way to resume an implausible lucky streak.
Katrielle stumbles upon a fresh mystery when a classmate of Ernest relates the story of a mysterious bus journey that seemingly transported them back to the time of their childhood.
The Agency is visited by a young boy named Leo who fears that the mysterious hero of London's streets, Ratman, has been kidnapped.
The team are summoned by Inspector Hastings to the site of a seemingly impossible burglary: one hundred million pounds have vanished from a high-tech bank vault.
Katrielle is called to the estate of a millionaire gourmet with an unusual request: her pet has gone missing, and she wants it found before her dinner party commences.
Rosa, an old acquaintance of Katrielle's father, visits the Agency with information relating to the Professor's disappearance eleven years ago.
The Agency attend the premier of a much-anticipated film, only to discover mid-scene that the moment of the climactic kiss has disappeared from the reel.
Relaxing on a public holiday, the Agency team become embroiled in a highly unusual case when a desperate Inspector Hastings pleads their aid in finding a last-minute gift for his wife's birthday.
Katrielle takes on a new case involving a young pianist who is being plagued by appearances of a doppelgänger.
Katrielle and co. are left puzzled when Hastings requests their help on a case where the culprit has already been uncovered.
The Agency receives a new mystery to solve when a young farmer details the unexplained appearance of strange patterns in their wheat fields.
Katrielle investigates a young girl on behalf of her concerned mother, who believes her daughter is able to predict the future.
Hastings turns to the Agency trio when London is menaced by a mysterious growling giant lurking in the fog.
Travelling on board the Molentary Express for a special solar eclipse tour, the team find their attention divided when clients old and new describe a sequence of strange events.
The team are summoned by a young heiress whose estate is seemingly being haunted by a host of ethereal apparitions.
Rosa returns to continue her story, and reveals the link between Katrielle's origins and the Professor's disappearance.
In search of sweets of legendary reputation, Katrielle is hooked when she is told that she will have to prove her connoisseur qualifications by locating the nearby store herself.
Katrielle is invited to the unveiling of Agency acquaintance and child genius Bengary's latest invention: Socketman, a robotic renaissance-manservant.
One of the famous Seven Dragons requests the team's investigative attentions after discovering a love letter written by his much-adored daughter, Allie.
Hastings employs the Agency's efforts in the search for a hand belonging to Big Ben in the hope of recovering it before the arrival of a foreign ambassador.
Katrielle joins the investigation into a tragic incident that took place on the River Thames during the city's Riverside Festival.
Ernest recounts the time he was accused of stealing valuable research papers on his first day at Gressenheller University, and, in doing so, his fateful first meeting with Katrielle.
The Agency team find themselves on the run from the law after Katrielle is accused of a murder.
Katrielle finds yet another mystery on her hands when a celebratory treasure hunt on a luxury cruise ship's inaugural voyage goes awry.
The Agency trio travel to the Highlands to investigate recent sightings of a strange "Nessie" creature at Loch Nem.
A new client, Hans, approaches the Agency after an encounter with an old friend whose appearance has seemingly remained unchanged after thirty-five years.
Strange goings-on in a domestic household lead the Agency's latest client to seek their advice on whether or not his wife has become a witch.
Katrielle takes on the task of reuniting a young woman with the object of her affections, a man who claimed to hail from another planet.
Bengary challenges the Agency team to solving their most ambitious case yet: a murder mystery from the realm of his own imagination.
On the tail of the fabled Relics, the Professor and Luke of eleven years prior close in on a shadowy figure, while Katrielle and co. trace their whereabouts in the present.
The paths of the two parties converge in Southampton as the final hours before the duo's disappearance count down.
Angel Arrow CEO Bergman calls on the Agency after the label's four showcase dresses vanish two nights before the world's biggest fashion show.
The Agency is visited by Mintan's fellow farmworkers, seeking the team's help after a sudden personality change in their old friend transformed him from hard-working farmer to rude gambler with an improbable perfect winning streak.
Katrielle joins a Scotland Yard blockade erected around a bridge due for demolition after a giant robot constructed by Bengary takes up residence. With the robot incapable of normal communication, Katrielle must figure out both how to get through to it and what the nature of its goal might be.
An Agencybound Katrielle receives a call from babysitter Kelly, whose concerns about her latest assignation appearing to include an invisible infant prompt the unflappable investigator to attempt to conduct a full inquiry over the phone.
Spurred by a horoscope warning that the only recourse to having "the worst day of the decade" might be to spend it with a friend, Katrielle decides to meet with Emiliana at a local café, unaware that the adroit analyst has her own plans. Emiliana challenges Katrielle to guess the professions of their fellow customers, pitting the former's highly professional profiling skill squarely against the latter's esoteric and intuitive investigation methods.
In the wake of discovering a recurring phantom figure appearing in his images, London Times photographer Pete contacts the Agency, fearing that he has fallen victim to a curse.
Tired of being treated like the Agency dogsbody, Sherl jumps at the chance to conduct his own investigation into the reported death of a beloved member of the neighbourhood pack.
The Agency trio are recruited by the head Dragon with the goal of completing a "virtual reality game".
After an incident involving an all-you-can-eat restaurant opening and Katrielle's insatiable appetite, the eager investigator accepts the offer of a cook-off challenge to settle her debt.
The youngest of the Dragons invites Katrielle and a selection of her acquaintances to compete in a game of "Ghost Escape".
The Agency trio's trip to the Marylebone Museum of Art to see the famous Mona Lisa takes a strange turn when Katrielle is informed that the museum's entire collection has been surreptitiously replaced with an array of Lisa-centric works.
Receiving an invitation addressed to her father requesting attendance of puzzle-solving event hosted by the mysterious Ariadne, Katrielle and company find themselves reunited with all seven of the renowned London millionaires at the deserted mansion of a deceased magnate.
Katrielle realises that the Seven Dragons are hiding a secret, and as she pieces everything together, the true identity of Lord Adamas is revealed.
In the wake of having located Luke and the Professor, Katrielle's investigatory instincts refuse to let her rest, compelling the team to follow the trail of the mysterious "Aldebaran" to his palatial home.
The two parties at last united, their path leads to the Greenwich Observatory for a final showdown with the man behind the entire conspiracy.