Former international CIA operative Wesley Cole returns home and assumes duty as a police officer with the LAPD. Cole will find himself navigating a new partnership with Murtaugh, as he adjusts to life in Los Angeles. Meanwhile, Avery continues his campaign for city council.
New partners Murtaugh and Cole attempt to find a steady rhythm as they work to solve the murder of a finance executive. Meanwhile, Cole navigates his role with his ex, Natalie, and his daughter, Maya, and Avery grapples with the outcome of his campaign for city council.
Cole juggles the realities of his job and his duty to be a good parent, as he and Murtaugh work together to bust a gang running a lottery scam. Murtaugh gets ready to celebrate his 30th anniversary with the LAPD and receives a surprise visit from his competitive father-in-law, Don Bennett.
Cole reflects upon his time working for the CIA, as a person from the past makes a startling reappearance. Murtaugh struggles with his own mistakes, after a murder raises questions about a suspect he put away years prior. Meanwhile, Leo Getz returns as the attorney on the case and tries to convince Trish to join his team.
Murtaugh and Cole investigate after a robbery of a truck filled with fine art. Cole deals with lingering feelings for Natalie after a development in her life. Meanwhile, Riana blackmails Murtaugh into letting her go to a concert after she catches him in a lie he told Trish.
Cole confronts his past when his former mentor, Tom Barnes, delivers alarming news, as he and Murtaugh investigate a robbery of safe deposit boxes. Meanwhile, Murtaugh clashes with Trish's new client, Louie Gutierrez aka "The Gute" and enlists Bailey's help to investigate her.
Murtaugh turns to Cole's former mentor, Tom Barnes, for help on a high-stakes cartel case. Meanwhile, Murtaugh and Trish meet Natalie and Maya for the first time, and tensions mount between Bailey and "The Gute", as the new partners begin to work together.
Cole wants to talk to Natalie about their relationship before it's too late, but a wrench is thrown in his plans after he bumps into a new ADA, Erica. Meanwhile, after being kicked out of the house for Trish's girl's night, Murtaugh finds himself an unlikely friend.
While Cole gets into the holiday spirit for his first Christmas with Maya, Murtaugh hopes he can convince RJ to come back home from Costa Rica for the holidays. At the precinct, Cole and Murtaugh are saddled with a complicated burglary and home invasion case. Meanwhile, Avery's holidays are a bit blue, and Bailey is still trying to figure out her new partner.
Cole finds himself on the rebound after Natalie's engagement, and his new romantic interest, Julie, has an unexpected connection to A.D.A. Erica, complicating things at work. Meanwhile, Murtaugh worries about the connection between the murder he's investigating and a new opportunity for Trish to serve as co-counsel on a high-profile lawsuit with Leo Getz.
Murtaugh takes a family vacation, but is pulled back into work when he witnesses an alleged abduction. Cole is left to investigate a murder himself, but the two cases begin to intersect. Meanwhile, Erica's mother, Senator Malick, comes to town and stirs things up between Erica, Cole and the case at hand.
Murtaugh and Cole investigate the murder of an underground MMA fighter when Murtaugh realizes his fighting moves aren't as sharp as they once were. Meanwhile, Trish is unfulfilled by her practice and considers running for a public office. Also, Cole and Erica try to keep things casual and uncomplicated but their plan backfires when Maya reacts to her family changes in a negative way.
When Cole and Murtaugh investigate a case involving a father and daughter crossing the Mexican border, they end up uncovering a major issue with California Boarder Patrol. Meanwhile, Trish prepares her campaign for D.A. and must face parts of her past, before they find their way into the media spotlight. Cole also confronts his past when he experiences flashbacks as a result of an injury.
Against Murtaugh's advice, Cole reaches out to Tom Barnes to help with a case that hits close to home, putting Murtaugh and Cole's partnership to the test. Meanwhile, Trish prepares to announce her campaign for District Attorney.
When Cole is investigated by the FBI, Murtaugh is forced to question his loyalty to his own partner. Meanwhile, Cole works a case that puts Natalie's fiancé, Andrew, into the crosshairs right before their wedding day.