In the new series, Lupin III will travel to France — the home of his grandfather and namesake, Maurice Leblanc's master thief character Arsène Lupin.
Lupin decides to steal digital currency from Marco Polo on the dark web and enlists the aid of the developer of the security system of the bank: Amlita (Ami). She lives in the Twin Towers, one above ground and one below water, but is weak from living on a poor diet. With Ami's help, they successfully transfer a fortune into Lupin's account. However, almost immediately upon their return to their hideout, Zenigata and his men surround the place. They discover that Zenigata easily found them because a new online game, "Arrest Lupin III" has gone viral with people posting sightings of Lupin. A chase the follows, with Lupin becoming increasingly frustrated at the intense pursuit.
The chase continues, with Lupin, Daisuke, Goemon and Ami arriving at an airport. They steal an electric car, but become trapped in a hangar by Zenigata and surrounded by the police. Within the hangar is an AW609 airplane, and with Ami's hacking skills, and the energy from the electric car battery, they start the plane and escape. They then board a cruise ship to Bwanda which is not an ICPO member nation so Zenigata cannot touch them. While there Ami wanders off and is attacked by street thugs, but is rescued by Lupin. They discuss her relationship with the team and Lupin says that she should stay with them for protection from Marco Polo. Suddenly they come under attack from bounty hunters. There is now a new online game, betting on the day Lupin will die.
Shinpei Mayama, the Rat Clan, Union Mama... the all-stars of assassination, from all over the world, suddenly come after Lupin. They're players in a new game started by the executives of Marco Polo: Happy Deathday. Ami uses her hacking to get Lupin out of trouble, but she's shot and injured in the process. With Jigen and Goemon also under assault, Lupin comes up with a plan to take out all the hired killers at once.
Fujiko smiles deviously as she points her gun at Lupin, when Zenigata arrives to save him and Ami. They get into the inspector's car which takes off, but it's soon attacked by soldiers who are trying to cash in the price on Lupin's head. Abandoning the car, they have to cross the desert on foot, a difficult task made harder by the presence of Zenigata!
Lupin is shot in the head by a drone fighter. With the death of its target, the Lupin Game is concluded. Time passes, and people forget about the game. Released from his duty of hunting Lupin, Ami now lives with Zenigata, when one day Goemon visits her. After receiving a message from him, she decides to confront the executives of Marco Polo.
This episode is an homage to the part 3 Lupin era.
In order to save their family workshop from foreclosure, a young inventor suggests to his brainless older brother that Lupin may be the answer to their financial problem. They build a smart safe for the Greater Tokyo Bank which can only be opened by someone with no brainpower. Is Lupin up to the Challenge?
Lupin is hired by his old friend Gaston to steal a certain painting from the vault of Mr. B, a compulsive art collector. The painting is a Picasso forgery ostensibly painted by Gaston's grandchild. Lupin succeeds in his heist, but he and Jigen end up being chased by the DGES. Lupin discovers that the painting is the hiding-place for a notebook containing information about sensitive crimes hushed up by the French police, evidence which would topple a number of high-level persons if its contents went public. Lupin then finds that the Gaston who hired him was an impostor, as the real one died a month ago. A clue reveals the involvement of Albert d'Andrésy, an individual from Lupin's past that he never wanted to see again.
At Gaston's grave, Lupin and Jigen encounter Camille Bardot, an ex-investigator with a phenomenal photographic memory and an old acquaintance of Gaston. After receiving a telephonic challenge from Albert, the three of them find themselves targeted by a number of assassins. Mortally wounded, Bardot reveals that he aided Gaston in copying the original black notebook in the hopes that, at the right time, justice could be served against the perpetrators, but in turn, they were ruthlessly hunted by DGES director Guillaume for it. Realizing that Albert set him up to gain possession of the notebook, Lupin returns to Paris to challenge him; but despite his precautions, Albert shoots Lupin a number of times, and recovers the notebook.
Before Albert's triumph is complete, Lupin is rescued by Jigen and Goemon, and the notebook is snatched from him by assassin-for-hire José and his minions. While recovering, Lupin reveals that Albert used to be his partner years ago but, not being satisfied with "small-time" thefts, turned away from Lupin to become the shadow ruler of France. Meanwhile, with the presidential elections approaching, José uses the book as leverage against the government, allowing terrorists to wreak havoc with impunity in order to swing public favor toward his patron, the right-winged election candidate Calvess. He also has his gang pursue Lupin and his friends because of their knowledge of the book's contents. With their respective interests at stake, Lupin and Albert join forces against their common enemy.
After forcing the DGES Director-General to reveal everything he knows about José, Lupin and Albert, assisted by Jigen and Goemon, storm the chief assassin's chateau and fight their way past Jóse's chief henchmen. When they find him and bring him down, Jóse, a cyborg, kills himself with an implanted bomb, but Lupin manages to retrieve the notebook. Despite Albert's final attempt to steal it back, Lupin retains his hold on it, and the two part ways with their past relationship (somewhat) restored. After Calvess and the DGES Director General are left defeated, Lupin re-buries the notebook in Gaston's grave.
This episode is an homage to the part 2 lupin era.
Just before New Year's Day, Lupin remembers a former caper in which he and his gang attempted to grab the legendary collection of Pablo, a notorious drug kingpin who disappeared in the South American jungle. Eventually, they discovered Pablo's secret hideaway for his collection of first-class vintage cars but found themselves challenged by a car which was strangely invulnerable to their attacks. Lupin dared his opponent to a race across Pablo's old jungle race track and won; the challenger was revealed to be the ghost of Pablo himself, and his car collection, long since overcome by degradation, to be nothing but scrap metal. In addition, they were hunted by Pablo's surviving family members, who were after the collection themselves, and their corrupt Brazilian Army cohorts. Although initially intent on fleeing on their own, Lupin, Jigen and Goemon ended up battling their pursuers together, while Fujiko just barely made her escape alone.
Goemon is coerced by Lupin into winning the confidence of the young woman Chloé Cazal. She was apparently a close friend of the late Belgian millionaire André Regnie, who gave her an immensely valuable gem necklace made before the Russian Revolution, which has made Chloé a target for the descendants of its original owners. While looking for her in the town of Sirena (and struggling with the attention of a local Anicon's visitors), Goemon befriends a boy named Jean who lives in Chloé's neighborhood. He moves into Jean’s parents' hotel to watch over her, spending all his money on expenses and fending off several hired assassins in the process. However, Goemon later discovers that the girl is actually the Chloé's daughter Inés and that her necklace is a forgery. Inés had acted as bait to enable her mother to sell the real necklace. In the end, with no money left, Goemon asks to stay with Inés to work off his accumulated hotel bill.
Lupin's next target is the Bloody Teardrop, a national treasure of the south-east Asian kingdom of Padar which is currently worn by the royal princess Dolma, a very independent and forceful girl. As fate wills it, Dolma attends the same boarding school as Ami and has even - as a fellow oddball - become friends with her. A terrorist group calling itself the Whales of Liberation occupy the school and takes the students and teachers (including Fujiko, who has infiltrated the Institute for the jewel) hostage. Fujiko frees Ami, and they team up to take them down from within, aided by Lupin's gang, who have also discovered the terrorists' presence. However, one of the teachers reveals himself as McGuire, a CIA special agent, who prepares to spirit Dolma away because, as he states, Pandar is in danger.