MacGyver follows the adventures of the laid-back, extremely resourceful secret agent Angus MacGyver. He prefers non-violent conflict resolution whenever possible and refuses to carry or use a gun. MacGyver works as a problem solver for the Phoenix Foundation in Los Angeles. Utilizing his education as a scientist and his experience as an operative in the Department of External Services (DXS), he is able to solve a range of problems usually with the help of his ever-present Swiss Army knife.
While helping the People's Republic of China secure a priceless national treasure—The Ming Dragon—in a San Diego museum, MacGyver runs into a Lisa, a woman that he had loved and thought was long dead. MacGyver learns that Lisa has been alive all these years and needs his help escaping the KGB.
The KBG have Lisa in their grasp, and MacGyver must get The Ming Dragon for them to free Lisa. MacGyver enlists the help of his old buddy, Jack Dalton, to help him steal it.
Jimmy Kendall, living undercover after testifying against his Mob bosses, surfaces when he becomes the manager for a winning baseball team.
While mapping the wilderness for the Phoenix foundation, MacGyver stumbles on a deserted ship and finds a runaway girl who tells him that the rest of crew was driven away by Bigfoot.
A jewel thief with diplomatic immunity kills Mac's friend. But there are more people involved in the crime - and Mac can't be sure who's on his side.
Mac and Nikki race to recover equipment from a downed experimental plane before the Soviets, who are using a psychic to guide them to the wreckage.
MacGyver and Jack Dalton are arrested in Arkansas by a corrupt sheriff who arrests people to make them work in a labor camp used for mining gold. MacGyver wants to escape, but Jack has other ideas: He wants to find five million dollars his uncle Charlie left in the mines years before.
MacGyver is forced out of his grief over the tragic death of a friend by a madman with a score to settle from their past association.
A desperate physics student goes off the deep end and boobytraps a college lab when he fails to win a science competition and to live up to his father's high expectations.
MacGyver teams up with colleague Nikki Carpenter to find out who is behind the attempts on her life. When they find out that the man who tried to kill her is connected to two terrorists who blew up a local post office, MacGyver and Nikki must find out what the terrorist's next target is before it's too late.
An impulsive scientist who cuts corners in her research work creates an uncontrollably mutating organism that speeds up the aging process.
While testing a new nuclear bomb defusing team at the Phoenix Foundation, a deadly explosion kills three men. Pete blames himself for not inspecting their equipment better and resigns from his job out of guilt. However, Pete is replaced by a not-so-trustworthy man—one who may have been connected to the explosion.
While back in Minnesota to fill in as coach for a high-school hockey team, MacGyver tries to change the attitude of a callous player who has a shot at playing for the pros. But when this kid's ambition lands another player in the hospital, MacGyver must try and find out what or who is pushing him so hard to succeed.
After returning home from a long assignment, MacGyver has an unwelcome surprise. Jack Dalton is waiting and wants him to help with a new scheme. A wealthy woman has just acquired some invaluable jewels, needing Jack to fly her back to her home in France. Things seem to be going fine, that is, until they land. Jack and MacGyver are arrested and accused of theft.
MacGyver becomes infatuated with a woman while conducting environmental-impact studies. However, what MacGyver does not know is that the woman was hired to "persuade" him to skip the studies—and if necessary, kill him.
MacGyver enlists a recluse nicknamed "Earthquake" to help find a person who is dumping toxic waste and polluting mountain streams.
Jack and Mac help an ancient Indian search for a wolf mask that two mercenaries are also eager to have.
Mac and Jack return from a flight to find an abandoned baby in Jack's hangar, complete with a desperate note from the mother and his own endowment fund hidden in his diapers.
While visiting an old girlfriend who's a park ranger at a wildlife reserve, MacGyver runs into deadly poachers who are intent on hunting animals on the reserve. When MacGyver tries to uncover their plot, they come after him. Now it's a race against time to escape the poachers, save the animals, and save their own lives.