Wolves face a tricky away trip to Old Trafford, where they have not beaten Manchester United since 1980. Gerard Houllier's Aston Villa side take on Fulham at Craven Cottage, while Blackburn host Wigan at Ewood Park in what is sure to be a keenly-contested Lancashire derby.
West Ham owners David Gold and David Sullivan return to Birmingham City for the first time since their 16-year association with the club came to an end in 2009, and Blackpool welcome Everton to Bloomfield Road for their first top-flight clash in 30 years.
Elsewhere, Bolton host Tottenham and Sunderland meet Stoke.
