Early 1960s sitcom about an architect named Wilbur Post and his talking horse, Mister Ed.
Wilbur is overwhelmed when he goes into his barn and his horse starts talking to him. Wilbur's wife and neighbors think he's crazy when he tries to tell them. Ed says that he will only talk to Wilbur and nobody else.
Wilbur is trying to win a contract to build a clubhouse, but Ed gets him into trouble and botches the idea.
Carol gets wrapped up in a woman's club and completely ignores Wilbur. It's up to Ed to try and help her overcome the obsession.
Wilbur and Carol plan a trip to go to a park and Ed's feelings are hurt because he feels left out. Ed then runs away to start a new life.
Ed becomes trouble when he knocks over a barbecue and then eats Carol's planted vegetables. After all this, Wilbur and Addison both end up having to sleep in the barn.
Ed is used as a team mascot and Wilbur must come to his rescue when Ed is stolen by a rival team.
Ed thinks it's silly to play in a Western play. But Wilbur persuades him to act when he tells Ed that a philly horse has fallen in love with Ed. Wilbur then talks Ed into returning back to the set.
Wilbur makes Ed angry when he takes the phone extension out of the barn. Ed reacts by playing tricks on Wilbur and Carol.
Wilbur's well deserving vacation plans come to a close when an annoying aunt with her talking parrot comes to visit for the duration.
Carol wants an antique statue and Wilbur won't let her buy one. She then tells him that she will go on a fish diet if she can't get the statue. She then buys it anyway and Wilbur finds it and takes it back. Finally Wilbur changes his mind and buys it for her anyway. She then takes it back. Then everyone it comes in contact to takes it back and when Wilbur comes to buy it for the last time, the store owner is bout to go crazy.
When Wilbur ends up in a Mexican jail after refusing to pay a repair bill to a mechanic to damaged his trailer, Ed comes to the rescue.
Ed bids for his mother at an auction when he finds out that his mother is used on a farm as a plow horse.
With the help of Ed, Wilbur picks a winning racehorse for Carol and his neigbors. Unfortunatelly they end up betting on a horse that Wilbur has mistakenly circled.
Through a musical experience, Wilbur has a music publisher record a song written, composed, and sung by Ed.
Wilbur and Carol adopt a puppy for an extra pet and Ed gets so jealous that he tries to get the pup in trouble so that Ed can get all the attention.
Ed is afraid of heights and Wilbur gets help from a psychiatrist to help Ed, unfortunately everyone around Wilbur think that the psychiatric help is for him.
Addison and Kate hire a 4 star cook who threatens to quit because there are no eligible men around the property.
A handman hired by Wilbur creates a problem when he squirts water on a photographer for a fancy magazine.
A new boy enters the neigborhood and none of the kids like him. To try and get the kid together with the other kids, Carol throws a party. Ed then hatches a scheme to show that the boy is brave by riding the "Mean" Ed.
Ed gets angry at Carol and thinks she is mistreating him because she has Ed hitched to a surrey when Wilbur refuses to buy her a new car.
Addison convinces Wilbur to grow a mustache to look older, so that he can land a promising architectual job he's been wanting.
To Carol's shock, Wilbur whispers the name of another woman in his sleep. After being mad and upset, she is relieved to learn that the name he mentioned was a female horse that Ed wanted him to buy for the barn..........and him Grrrrrr.
Ed manipulates Wilbur to try and get him to play chess with him, but Wilbur doesn't believe him when Ed tells him that there is a burglar loose in the house.
Ed toutors Wilbur on everything from reference books to foreign languages to win a contest that awards $5,000.00.
Ed protests when Wilbur and Carol go to Pine Lake Lodge for vacation. Despite his protests, they leave him behind this time anyway.