Early 1960s sitcom about an architect named Wilbur Post and his talking horse, Mister Ed.
Ed, who is a die-hard Dogers fan, notices some weaknesses from the line-up while watching a televised game. Ed then takes it to the field when he himself bats a few and slides onto bases himself at the L.A. Dodgers Stadium.
Addison gets Wilbur to come up with a design for a building that Addison wants to build. Ed then distracts Wilbur with ideas for a horse book.
The city's American History Museum offers Wilbur a task to build a monument. The best part is that they offer Wilbur a commision, but he doesn't know what he should create.
Ed enters Wilbur in a newspaper puzzle contest and Wilbur ends up winning a little horse whis Ed adopts as his own son.
Wilbur and Ed get lost while they were riding out. As they got lost, they met a few bums and while Wilbur's attention was caught by something else, Ed invites them to stay at the Posts' home.
Wilbur is offended by Kay's brother, who dresses up as a horse for a costume ball.
Ed has adopted a wild goat and decides to give it to Wilbur as a birthday present.
Wilbur is paid to build a brand new beach house for a popular female columnist.
Ed falls madly in love with a French female horse, but is turned off a little when he realizes that she is taller than him.
Wilbur's former Air Force commander, Gordon Kirkwood and his wife Winnie come to town and park their trailer in the Post's back yard. As the trailer is sitting there, Ed feels that his territory is being invaded.
Kirkwood officially buys the house next door, which causes Wilbur to go back to his old behavior of when Kirkwood commanded Post in the Air Force. This causes Wilbur to become overly helpful and just a pain in Gordon's neck.
Christmas time comes around the Post household and this year, Wilbur decides to be a little bit more frugal in buying gifts..... that is until he gets Ed's Christmas list.
The Posts and Kirkwoods look after a neighbor's baby, which in turn makes Ed feel neglected, which in return causes him to get the mumps.
Ed constantly is complaining about a toothache. Wilbur tries to fix it by hiring the vet to come and take a look at Ed. When Ed sees the needle from the shot he os about to get, Ed disappears from the scene.
Wilbur is invited to attend a convention held by a bunch of magicians (The Great Blackstones), and decides to take Carol and Ed along also.
Ed is frustrated when Wilbur hires a secretary who happens to be a Japenese exchange student. The reason Ed is so angry is because she is always there and Ed can't speak to Wilbur which causes him to get frustrated.
After a fight with Wilbur, Ed heads for all open land which in turn takes him to the desert which he falls victim to all types of misadventures.
Ed is offended when he is constantly called a jackass all the time, so Ed insists that Wilbur take him to the vet to make sure that Ed is still a horse.
Ed wants Wilbur to take him to a Gypsy to get his hoof read on account of if he will get with a Spirited Philly who he is in love with.
Ed becomes friends with an old swayback horse, who everyone riducules, and convnces Wilbur to let the horse stay with them.
Ed overhears Mae West commisioning Wilbur on creating ultra deluxe stables for her horses. When Ed ovehears the conversation, he starts to get discontented with his own surroundings.
Ed tells Wilbur that there is nothing to driving a car. Wilbur scoffs at the idea and Ed must show up Wilbur.
Everyone gets involved in a local variety show, which makes Ed feel left out. Ed then concocts a plan which he can be a one-horse band and starts to practice in the barn after midnight.
While a prowler is loose in the neighborhood, Wilbur plays detective while Ed is holding the prowler.
Wilbur refuses to buy Ed a new saddle and Carol a new dress.