When former fashion model Maddie Hayes goes broke and finds that one of her few remaining assets is ownership of the Blue Moon Detective Agency, she is tempted to liquidate it until she meets the quirky employees and gets involved in their even quirkier cases.
An angel from above visits Baby Hayes as he waits to be born and gives him the low down on his parents and their relationship.
Maddie takes on several new cases in an effort to bury her sorrow, including one where a woman is convinced that her husband is still in love with someone from his past.
Maddie and David struggle to find a new footing for their relationship while working on a case for a woman whose husband of one week returns after a ten year absence.
Maddie and David are hired by a disfigured man who has become a recluse and needs the detectives' help in proving that a plastic surgeon wantonly caused his disfiguration.
The office divides along gender lines when Maddie takes on a case for a woman who shot her boss for sabotaging her career when she refused his sexual advances.
A ruthless divorce lawyer comes to Blue Moon for help in reconciling a couple she helped split up, and Maddie tries to buy David a present.
Dave and Maddie keep company with a popular corpse and visit a graveyard when a man seeking a bodyguard drops dead in their office.
Maddie is sympathetic while David is skeptical when his brother shows up asking for help tracking down his fiancee's former partner, who has absconded with all their company assets.
Maddie resists, but David plunges ahead when a dying burglar asks for their help in proving he committed the perfect crime 25 years earlier.
David goes beyond the call of duty to help entertain Maddie's cousin Annie, and Maddie realizes that David may be over his obsession with her.
Burt pouts and frantically tries to solve the crime when Agnes is forced to miss his family reunion because she won't vote to convict a man of murdering his partner / lover.
Dave helps Maddie entertain her cousin Annie, who's visiting California to get a perspective on her marriage.
Dave breaks it off with Annie when her husband comes to California, everyone attends the wedding of Burt and Agnes, and the agency closes its doors for a final time as everyone tries to figure out why it all had to end.