Myself ; Yourself is set in 2007 in the fictional town Sakuranomori (桜乃杜?) in W Prefecture which is modeled after Wakayama Prefecture, Japan. The town is in a quiet, rural area on the southern tip of the prefecture and borders the Pacific Ocean. Sakuranomori is the birthplace of Sana Hidaka, a sixteen-year-old high school student, who grew up with his childhood friends Nanaka Yatsushiro & Aoi Oribe, his best male friend Shusuke Wakatsuki, and Shusuke's twin sister Shuri Wakatsuki. Sana left Sakuranomori when he was eleven years old, but returns five years later living on his own in the apartment building Aoi's family runs. Sana soon finds out that while some things have stayed the same, there are still just as many things that have changed.