The NCIS's New Orleans field office investigates criminal cases affecting military personnel in The Big Easy, a city known for its music, entertainment and decadence. Leading the team is Special Agent Dwayne 'King' Pride, a native of New Orleans who is driven by his need to do what is right. Working with him is Special Agent Christopher LaSalle, who plays hard but works harder; and Special Agent Meredith 'Merri' Brody, a charismatic and tough interrogator who transferred from the Great Lakes office in search of a fresh start. Supporting them is coroner, Dr. Loretta Wade, who is as eccentric as she is smart. This colorful city that harbors a dark side is a magnet for service personnel on leave, and when overindulgence is followed by trouble, Pride's team is at its best.
While Pride remains on probation six weeks after his rogue takedown of the corrupt Mayor Hamilton, his team is closely monitored by Supervisory Special Agent Paula Boyd. Also, when the FBI arrives to run lead on a case involving a stolen big rig of nuclear waste, the team must secretly investigate from the sidelines.
While preparing to leave on a fishing trip, Martha Roberts, an erratic whistleblower who calls Pride her mentor, kidnaps him to help her locate a serial killer targeting young women in the Gulf of Mexico.
Pride and his team join forces with FBI Director Isler after a Russian operative, who’s in the states to provide intelligence on sleeper agents, disappears after his Navy escort is murdered. Also, Tammy partners with former sleeper agent Eva Azarova to locate the missing operative who Eva has known since childhood.
The NCIS team investigates the copycat murder of an unsolved case from 150 years ago that spawned a legendary New Orleans ghost story. Also, Gregorio is spooked when the case is connected to a recent séance and a local medium.
Sebastian is placed on administrative leave after his response in a foot chase to apprehend a high value fugitive is questioned by the FBI. Also, while Pride and the team continue to track the high value target, they attempt to find a way to clear Sebastian’s name.
The murder of a petty officer leads Pride and his team to a mysterious woman who is targeting men with high security clearance. Also, Lasalle’s father, Beau, arrives in town to discuss the family business.
NCIS is called in to investigate after a clinical trial of brain implants in Veterans is hacked. Also, Patton must work alongside his ex-wife, Doctor Anna Yoon.
Wade's son, Danny, calls Pride for help after he's attacked at his girlfriend's house and she is now missing. Also, the director of NCIS mandates that Pride meet with a therapist to discuss his process for solving cases.
Pride second-guesses evidence suggesting homeless kids are the suspects in the murder of a petty officer.
After Rita Deveraux tells Pride that Douglas Hamilton is about to make a deal to get out of prison, Pride and the team rehash the Clearwater case in hopes of locating his mystery partner and spoiling his bargaining chip.
After a deadly armed robbery and high-speed chase is connected to an undercover ATF operation, Percy reconnects with her former ATF partner, Jake Roman.
Sebastian receives a plea for help from his high school friend Adrian Cohen after her business partner is killed at the Crescent City Gaming Convention. Also, FBI Special Agent Raymond Isler believes Adrian is a hacker the Cyber Crimes division has been tracking for years.
A petty officer’s murder leads the team to a family-owned night club where Pride’s mother used to perform weekly. Also, Lasalle must urgently return home to Alabama after receiving an unexpected call from his family.
The NCIS team investigates the murder of a petty officer who was in town to help a refugee family being recruited by terrorists. Also, Wade works on the special election campaign for Mayor Zahra Taylor that takes place during Mardi Gras.
FBI Special Agent Raymond Isler asks Pride for help with an off-the-books opioids theft investigation he is personally invested in. Also, Percy is sent undercover as a getaway driver with Isler as the muscle for a job tied to the case.
NCIS investigates the disappearance of a congressional aide after a hitman saves her from two men posing as NCIS agents. Also, Lasalle struggles with life-altering decisions regarding his brother’s future.
During the annual Contraband Days pirate festival, the NCIS team investigates the murder of a Navy captain who was searching for a valuable 200-year-old marble and gold fleur-de-lis.
Pride, Sebastian and Tammy travel to South America after Pride is personally requested by a former colleague to assist with a classified operation that has been compromised.
Percy and Lasalle go undercover at a high-stakes, underground poker game after the organizer targets players with access to a naval research laboratory. Also, Laurel Pride visits her dad during spring break to discuss options after her upcoming graduation.
Pride and his bar patrons, including Sydney Halliday who is visiting Pride after leaving the Army, are held hostage by a group of volatile thieves.
Gregorio calls on Claire McGrady, her former behavioral science professor, when the team’s latest case matches one she studied during FBI training.
When journalist Oliver Crane posts a scathing article documenting Pride’s “reckless use of justice,” the team is concerned about the fallout from the piece and the confidential information included in the story. Also, Rita Devereaux warns Pride that someone in D.C. has coordinated this attack on him, and the article is just the beginning.
Pride assembles an off-the-books team with hacker Elvis Bertrand, retired Green Beret Sydney Halliday journalist Oliver Crane and attorney Elliott Newman, to search for a loophole when he faces a grand jury indictment for abuse of power.