The NCIS's New Orleans field office investigates criminal cases affecting military personnel in The Big Easy, a city known for its music, entertainment and decadence. Leading the team is Special Agent Dwayne 'King' Pride, a native of New Orleans who is driven by his need to do what is right. Working with him is Special Agent Christopher LaSalle, who plays hard but works harder; and Special Agent Meredith 'Merri' Brody, a charismatic and tough interrogator who transferred from the Great Lakes office in search of a fresh start. Supporting them is coroner, Dr. Loretta Wade, who is as eccentric as she is smart. This colorful city that harbors a dark side is a magnet for service personnel on leave, and when overindulgence is followed by trouble, Pride's team is at its best.
While Pride fights for his life in the ICU, the team scours the city for the hit woman who attempted to assassinate him.
As the team searches for a former IRA bomb-maker who was smuggled into the city, they are joined by Special Agent Hannah Khoury, Pride’s replacement during his medical leave. Also, Pride considers a new position with the agency.
While NCIS investigates the murder of a Navy intelligence officer killed during a conference for foreign diplomats, the key witness cozies up to Sebastian. Also, Pride has some trouble adjusting to his new position at the agency.
After a petty officer is found murdered under a shrimping boat, the NCIS investigation uncovers a conspiracy in the tight-knit local fishing community. Also, Lasalle awaits the final results of the tax fraud investigation into his family’s company.
Pride’s father, Cassius Pride, is wrapped up in an NCIS case involving a notorious unsolved casino heist from several years ago. Also, Pride meets a family member he never knew existed.
After Pride’s assistant, Ginny Young, escapes from a kidnapper, the NCIS team uncovers evidence of a suspect who is harvesting organs from multiple victims. Also, Pride turns to his friend, Commander Calvin Atkins, M.D., for medical and spiritual guidance as he struggles with the ramifications of his recent brush with death.
Following a deadly car explosion in the French Quarter, the NCIS team interrogates a professor and former member of a student protest organization. Also, Tammy discovers a secret about Hannah’s personal life.
The NCIS team places Mateo Diaz, a high school gang member turned informant, in protective custody while they investigate the murder of his junior reserve officers’ training corps instructor. Also, Pride needs his brother Jimmy Boyd’s help to gain Mateo’s trust.
The NCIS team investigates the murder of a Navy contractor who, unbeknownst to anyone, lived two lives for decades, with two wives, families and careers.
While on a sunrise jog, Pride is grabbed by two masked men who order him to complete a series of tasks in order to save Wade and his father, Cassius Pride, who are being held captive.
Pride and the NCIS team hope to take down a secret and lethal group of former intelligence agents and avenge the death of someone close to them.
While undercover, Gregorio joins a social club for military wives after one of the members is contacted by an ex-boyfriend on the FBI Most Wanted List.
NCIS investigates the disappearance of a Navy entomologist after a deadly shooting at a research lab. Nero, with Naval Intelligence, joins the investigation when the team discovers a rare and deadly virus was also stolen.
Pride and the team reunite with conspiracy journalist Oliver Crane after the source for his latest vigilante story is murdered. Also, Hannah’s former partner, Liam Somers, surprises her in New Orleans and shares a shocking revelation about an old case.
The team investigates multiple murders tied to a construction company creating an experimental chemical that strengthens sea walls. Also, evidence from Hannah’s previous mission in Oman is used against her as blackmail.
After an elusive terrorist with a personal vendetta against Hannah resurfaces, she is placed in protective custody with her family while the NCIS team searches for the suspect’s whereabouts.
After a reshuffling of assignments, Pride is no longer Special Agent in Charge of the Southeast and returns to the New Orleans NCIS office during the investigation of a missing petty officer.
The NCIS team investigates the murder of Patton’s friend, a former Navy Seal gunned down in a drive-by shooting while Patton helplessly watched.
After a Navy Lieutenant from a well-connected and affluent New Orleans family has a fatal fall down a flight of stairs at a charity gala, the NCIS team investigates whether his death was an accident or foul play.
When Elvis Bertrand’s “daughter” is linked to an NCIS murder case, he asks Pride to prove her innocence.
Tammy is convinced that a con man committed the hit-and-run murder of a Navy doctor, even though the evidence shows otherwise. Also, unbeknownst to Hannah, her husband, Ryan Porter, approaches Pride with new intel on Apollyon, the underground spy network responsible for murdering his father.
The NCIS team investigates a deadly bombing at a military museum event with over 1,000 people in attendance.
Pride and Lasalle travel to war-torn South Ossetia in Russia to locate FBI Special Agent Raymond Isler, who was kidnapped during a failed mission to apprehend the leader of Apollyon, the underground spy network responsible for murdering Pride’s father.
After tracking Apollyon, a deadly underground spy network, to war-torn South Ossetia, Pride is separated from the team and faces grave danger. Also, in order to save Pride, the NCIS team must locate a mole who continues to feed information to Apollyon.