Life in a small city needn't be boring. Not when your city is home to a host of deeply odd people. Granted some residents, like high-school buddies Mio and Yuko, are fairly normal. Yuko is a world-class space-case and Mio has an unusual mastery of wrestling and boxing, but... okay, so they're odd too. Together with fellow residents such as Nano, the frequently modified robot of five-year-old genius the Professor, talking cat Sakamoto (that's Sakamoto-san to you!), and their own friend, the poker-faced lunatic Mai, they lead provincial lives that are perfectly mundane and thoroughly bizarre.
Mio Naganohara tries to comfort her friend Yuko Aioi when she gets a 1% score on a test. Meanwhile, robotic girl Nano Shinonome tries to give the small 'Professor', who has a cold, some medicine, which she refuses to eat, and tries to get advice from their talking cat, Sakamoto. Finally 'professor' eat the medicine that Shinonome mixed the medicine with pudding called Crunchy pudding. Later, Yuko, Mio and their friend Mai Minakami go on a train ride, which is completely empty at this time of the day.