Every day the girls face life, death and lunacy on the wards of St. Margaret's; every night they let off steam, with a dangerous appetite for uncomplicated sex and unruly misbehaviour.
Beth is up to her usual tricks once again, as she has set her sights on 'Trust-Fund Joe', the son of a particularly wealthy patient, who she thinks will be her ticket to a holiday in the sun.
However, this romance is short lived when Sean, a friend from Beth's past, reappears asking her to steal drugs for him. Unfortunately for Beth, Jamie spots her stealing the diazepam and threatens to report her. It's up to Lia to save her bacon with a spot of blackmail.
Anji is completely in love with Callum, even though he's still going out with Daisy. He confesses to Anji he is in love with both girls, which doesn't impress Anji one bit. By the time Callum realises that it's Anji he wants it's too late; he walks in on her shagging Dr. Vincent in the linen cupboard.
Nightmare Ward Sister Clare is annoying everyone by sucking up to the doctors, so Kate draws the short straw and is nominated to tell her how the nurses are feeling. Unfortunately, Clare breaks down when she hears Kate's criticisms and once Kate shows some sympathy she unwillingly becomes Clare's new best friend.
It's Easter and for Lia the pressures of work are mounting up. When the nurses are encouraged to pen a story for the ward's creative writing initiative, Lia lets rip. She writes a moving yet harrowing description of her depression after giving birth to daughter Emma, which impresses the course leader so much she enters it into a competition. Lia decides to resign from the job she hates so much to pursue her writing but Emma is furious at the news; she knows Lia's going to go off and leave her again and ends up reading her mother's story. She is devastated.
Meanwhile, Beth has a patient who has crucified himself and constantly refers to her as Mary. She soon realises that he's in ecstasy each time she tends to his nail wounds and is horrified to learn he is not thinking of the Virgin mother but fantasising about her as Mary Magdalene.
Anji has decided it's time she stopped sleeping around and looked for Mr Right. As part of her plan, she persuades the girls to go speed-dating with her. The night comes up trumps when Anji meets Alex and Beth meets Nigel.
However, four days after, Anji is yet to hear from Alex and finds comfort in the arms of the hospital porters. Beth, on the other hand, is the one doing the dumping when she discovers that Nigel has a daughter.
Meanwhile, there's an outbreak of MRSA and Dr McManus is on the rampage. As usual, he blames the nurses and Kate is appointed infection control nurse. Lia decides it's time to end the enmity between doctors and nurses by helping Jamie out of a fix, but when neither of them can bring themselves to trust the other, it all begins to fall apart.
Kate breaks the nurses' golden taboo and starts dating a patient, Robert. As Robert becomes increasingly ill, Kate finds she's compromising herself both as a nurse and a girlfriend and comes to the conclusion that she doesn't much like sick people.
Beth is increasingly irked by Jamie's unctuous social climbing in his attempt to become registrar, and determines to bring him down a peg or two.
Lia has to look after her daughter Emma's school rabbit as a symbol of her responsibilities as a parent, while Anji volunteers to help a PHD psychology student who becomes convinced she's on the verge of a mental breakdown.
The Trust are looking for 'the face of Yorkshire' nurses to star in posters and documentary-style adverts for their new recruitment campaign. Although Beth's cynical, the other girls are excited and think Kate would be perfect for the job. However, Beth is not quite so cynical when she finds out that she is 'the face'.
Student nurse, Simone, confides to Beth that she's got a crush on a doctor. Beth jokingly tells Simone if she wants him to notice her she should be really forward with him so that's exactly what she does...
Jamie's obvious glee at having scored with a 16-year-old is too much for Beth and she decks him in front of the ad campaign's cameras. Jamie's furious at being hit by yet another nurse and as the girls and the doctors try to pull them apart the whole ward descends into chaos.
Jamie's quest to become registrar has lead him to desperate measures. It's the annual hospital ball and, to impress the powers that be, Jamie asks Lia if she'll pretend to be his fiancée.
At the ball, senior consultant Mr Asquith is clearly very impressed with Jamie's choice of bride. However, when Lia takes a fag break at the bar, she pulls Marcus, a medical sales rep. As they share a post-coital fag, Marcus asks if he can see her again but Lia is not to sure...
Kate finds herself rushed in to A&E and is horrified to find herself a patient in her own ward, and Anji and the girls are
Anji's cousin Sujata has called up in a crisis. She's had a huge row with her parents and needs somewhere to stay.
Meanwhile, Kate's been accepted onto a Medical Nurse Practitioner course, which will give her advanced skills on the ward. When Jamie asks Lia to accompany him to another function as his fiancée, Lia's daughter, Emma, is quick to organise Marcus as her babysitter.
Elsewhere, Beth has a dinner date with new registrar Dr Tim, but she's convinced he's a nutter when he starts behaving very strangely.
Jamie has finally been made registrar and Kate gets tipsy on the celebratory cheap champagne. At the water cooler, she meets Dr Templar, makes a fool of herself and ends up agreeing to go to an Alcoholics Anonymous meeting.
A new agency nurse, Justyn, has already got on Beth's nerves because she thinks he's trying to pull her. After biting his head off, Beth eventually agrees to go for a drink with him, when the girls break the news that he's actually gay.
Meanwhile, Callum is convinced that a dishevelled looking man is stalking Anji and persuades her to tell him he mustn't come to the ward anymore. And Lia realises she's not in love with Marcus, even though he is quite clearly besotted with her.