"Nurse Jackie" is a half-hour comedy that is at turns wicked, heartbreaking and funny. Edie Falco stars as the title character Jackie O'Hurley, a strong-willed and brilliant -- but very flawed -- emergency room nurse in a complicated New York City hospital. A lapsed Catholic with an occasional weakness for Vicodin and Adderall to get her through the days, Jackie keeps the hospital balanced with her own kind of justice. Every day is a high wire act of juggling patients, doctors, fellow nurses and her own indiscretions.
After breaking up with Kevin, Jackie has to realize she needs professional help. Meanwhile, a new director at the hospital makes some personnel changes and Kevin finds out about Jackie and Eddie's affair.
Going through rehab, Jackie opens up about the beginning of her addiction. Meanwhile, Coop is the only one being excited about Cruz's ideas.
Worried about her daughter, Jackie leaves rehab early against her therapist's advice and finds that returning to work greatly rattles her nerves, forcing her to struggle to maintain her sobriety; Zoey has second thoughts about her relationship with Lenny; Eddie tells Jackie that he confessed their affair to Kevin.
Jackie catches Grace with a boy at a carnival and takes her, not before deleting the number from the boys phone. While at the carnival, Grace announces to Fiona and Zoey that Jackie went to rehab. Jackie goes to an AA meeting with Charlie only to find out that he is using again. Kevin forced Eddie to tell him what Jackie took, when they were having the affair, before telling Eddie to tell Jackie to "Kiss her kids goodbye". Jackie almost relapses when a patient gives her their medications. She throws them in a dumpster and then tries to retrieve them and falls in. She then gets out and walks away pill free. Charlie is revealed to be Dr.Cruz"s son.
Missing her family and adjusting poorly to single life, Jackie invites Kevin to meet her at a cafe but finds herself served with divorce papers instead of lunch; an attempted double suicide trauma case comes into the E.R.; Cruz institutes a draconian new dress code that is not a hit with his staff; Zoey looks for a new roommate and finds one in the lonely Jackie.
Jackie has a disturbing dream about using; Zoey loses her ring.
Jackie covers for Cruz when he has a panic attack; Zoey surveys her coworkers for the best ways to conduct a breakup; Akalitus enlists the staff in an elaborate charade when her mentor is admitted with dementia.
When Cruz learns about Jackie's rehab, he takes revenge on coworkers who have been covering up her drug problems. Meanwhile, Eddie is deposed by Kevin's lawyer; a dumped Lenny decides to take off for Europe; and Coop accompanies O'Hara to her ob-gyn appointment.
Things get out of control in the emergency room due to the recent firings and an overflow of patients who have been diverted from another hospital, causing Cruz to suffer a pulmonary episode and Jackie to step in. At home, a rebellious Grace refuses to go to class unless Jackie transfers her to public school.
While Cruz is in care, Jackie goes over his head to get the ER under control, resulting in her dismissal from All Saints for insubordination. Jackie pulls Grace out of Catholic school. O'Hara goes into labour and Jackie returns to All Saints in spite of Cruz. Charlie arrives at the ER and Cruz asks Jackie to help him save Charlie's life.