"Nurse Jackie" is a half-hour comedy that is at turns wicked, heartbreaking and funny. Edie Falco stars as the title character Jackie O'Hurley, a strong-willed and brilliant -- but very flawed -- emergency room nurse in a complicated New York City hospital. A lapsed Catholic with an occasional weakness for Vicodin and Adderall to get her through the days, Jackie keeps the hospital balanced with her own kind of justice. Every day is a high wire act of juggling patients, doctors, fellow nurses and her own indiscretions.
Whilst in jail following her arrest, Jackie suffers through detox. Expecting a confrontation with Gloria Akalitus, Jackie approaches a lawyer with her return to All Saints.
Jackie sets her sights on returning to All Saints, aided by her pit bull lawyer — the problem is she can’t afford to pay his retainer. Strapped for cash, Jackie gets inventive, turning to her old habits for a solution. Jackie goes toe-to-toe with Kevin after discovering his financial duplicity. Zoey struggles with the news that Jackie may be returning to the ER.
Jackie is on the floor again but back to square one. Under the Diversion Program, she cannot touch patients or medication and undergoes mandatory daily urine screens. But in her new role, she learns two big secrets with which she must contend. Akalitus makes it clear that she isn’t going to make life easy for Jackie. Just as the tables have turned in her relationship with Jackie, Zoey learns the outcome of her Master’s program application. Carrie withholds news about her pregnancy from Coop.
Akalitus doesn’t trust Jackie when she shares the news that the hospital is being sold to Norwegian developers. Carrie meets Coop’s proposal with an unexpected reaction causing him to make a major life decision. Still strapped for cash, Jackie’s dealing takes a surprising turn.
Jackie stirs up trouble when she rallies her co-workers against the developers, but an attractive offer challenges her allegiance. Coop prepares for his last day at All Saints while Carrie is confused by his excitement about leaving. Dr. Bernie Prince, Coop’s replacement, arrives and surprises everyone with his carpe diem attitude.
Jackie, Dr. Prince and Akalitus are forced to run the ER without nurses when Zoey leads a walk-out.
Jackie and Eddie make one last purge of their stash; Zoey blames herself after a patient dies.
When Jackie tells Grace about her news, Grace's reaction surprises her.
Jackie and Zoey set out on an unexpected road trip; Zoey confronts her frustration with Jackie.
Jackie and Eddie's nice quiet morning is ruined by an unexpected knock at the door.
Jackie has to perform a procedure when Dr. Prince manages to endanger a patient. A secret shocks Zoey.