Book Four finds the Frasers in North Carolina, in a place called Fraser’s Ridge at the cusp of the American Revolution. As Claire and Jamie build their life together in the rough and dangerous backcountry of North Carolina, they must negotiate a tenuous loyalty to the current British ruling class, despite Claire’s knowledge of the bloody rebellion to come. Along the way, the Frasers cross paths with notorious pirate and smuggler Stephen Bonnet in a fateful meeting that will come back to haunt the Fraser family. Meanwhile, in the 20th century, things heat up between Claire and Jamie’s daughter, Brianna Randall and Roger Wakefield, the historian who helped search for Jamie in the past. But as they grow closer, the young couple realize they have very different ideas about the future of their relationship. However, when Roger and Brianna search for proof that Brianna’s parents reunited in the 18th century, a shocking discovery makes them both consider following in Claire’s footsteps.
Claire and Jamie cross paths with Stephen Bonnet, a pirate and smuggler who enlists their help. Claire illuminates Jamie on some of America's history, leading him to wonder if it's possible for them to lay down roots.
Claire and Jamie visit his Aunt Jocasta at her plantation, River Run. When tragedy strikes at the plantation, Jamie and Claire find themselves caught between what's right and the law of the land.
Jamie and Claire search for a place to call home; meanwhile, in the 20th century, Brianna and Roger's romance heats up and then fizzles during a road trip that winds up highlighting their differences.
Having been led by providence to Fraser's Ridge, Jamie, Claire and Young Ian begin to build a home in the Blue Ridge Mountains. In the 20th Century, Roger tries to reconnect with Brianna.
Claire's medical expertise proves invaluable, but she begins to fear for her life when tragedy strikes her patients' household. Jamie and Young Ian travel to a nearby town to recruit settlers for Fraser's Ridge.
Jamie and Claire are surprised when Lord John Grey drops in on Fraser's Ridge with an unexpected traveling companion. When Grey takes ill, Claire must reconcile her personal feelings with her duties as a doctor.
Brianna follows in her mother's footsteps and travels through the stones back in time to 18th century Scotland where she struggles to make her way to the Colonies to find her parents.
Roger's diligent search for Brianna pays off when he finds her in Wilmington, but their romantic reunion comes to an abrupt halt when she discovered pertinent information that he intentionally kept from her.
As Brianna struggles to compartmentalize the trauma she suffered in the wake of the tragedy that befell her in Wilmington, she refocuses on finding her parents.
The secrets Jamie and Claire keep from each other as they try to help Brianna process her recent trauma cause a bigger familial rift once they are revealed.
Jamie, Claire and Young Ian embark on a long uncertain journey to rescue Roger. Brianna forges a friendship with one of Jamie's old friends as she fends off Aunt Jocasta's attempts to secure a husband.
Brianna confronts a violent figure from her past in an attempt to cope with her trauma. Roger befriends a fellow captive and endeavors to escape the Mohawk Village. Fergus and Marsali plan a dangerous mission.