It’s time for Ash and Pikachu to set off on their adventures in the Kalos region! Along the way, they’re joined by some new friends—a genius inventor named Clemont, his little sister Bonnie, and Serena, a Trainer on her first journey. Ash immediately tries to challenge the Gym in Lumiose City, but doesn’t get very far before a robot throws him out! In between Gym battles, Ash and friends will be exploring this unique region, meeting all kinds of new Pokémon, and looking into a fascinating new Pokémon mystery!
Ash arrives in the Kalos Region with Alexa, who reveals her sister is a Gym Leader, but she seems to be away.
Ash heads to Professor Sycamore's laboratory, where he discovers the professor is investigating a strange looking Garchomp. Team Rocket overhears the conversation and tries to steal Garchomp for themselves.
After Ash registers for the Kalos League, he encounters a Pokémon called Dedenne and a Fletchling, whom his newly captured Froakie does his best to battle.
Clemont tries to capture the Dedenne that keeps stealing their food.
Ash and his new group of friends finally meet up with Alexa in Santalune City where she introduces Ash to her sister, the Gym Leader Viola. Ash has his first Gym Battle in the Kalos Region, but he is defeated when Viola's Bug-type Pokémon put up too good a fight. Afterwards, an old friend reunites with Ash.
Ash challenges Viola to a rematch, now ready for Surskit's freezing strategy.
Ash is introduced to the world of Rhyhorn racing, and Serena, whose mother is a famous Rhyhorn racer, coaches Ash in the upcoming race. Meanwhile, Team Rocket has their sights on capturing Pikachu and the Racing Rhyhorn.
In the next town, the guidebook reveals that it is home to Charisma Trimmers, people whose expertise is styling the Pokémon Furfrou. Jessica, a Charisma Trimmer in training, is having problems with her confidence, which is only exacerbated by the expert Charisma Trimmer Moussalli, but she is not all who she appears to be.
Upon returning to Lumiose City, the group meets up with Clemont's and Bonnie's father Meyer who reveals to Ash and Serena that Clemont is Lumiose City's Gym Leader. Meyer also reveals that the Clembot, a robot Clemont had built to look after the gym in his absence, has gone haywire. Ash and Clemont infiltrate the gym to beat the Clembot in a Pokémon battle to take back the Lumiose Gym.
Before heading to Cyllage City, the group decides to stop by the Sycamore Pokémon Lab. Team Rocket decides to kidnap Professor Sycamore, as well as Serena and Bonnie, to pry the professor's mind for the secrets behind Mega Evolution, while Ash and Clemont have to deal with a gluttonous little Chespin with a penchant for macarons.
While on their journey, the group stops for lunch when they are interrupted by two Pancham. However when Team Rocket attacks, the Pokémon get separated from their trainers. As Ash and his friends try to reach Pikachu, so does Team Rocket, but they cross paths with a Pangoro along the way.
While heading towards the next city, the group sees a man escaping from Officer Jenny and along the way find a Scatterbug that fell out of the man's truck. It turns out that the man is a Pokémon poacher who has been capturing Vivillon of different patterns and the group decide to help Jenny catch him.
Ash and the group comes across a girl named Penelope who asks to battle Ash and if she wins he has to go out with her.
When Ash and his friends are caught in a rain storm, they find a nearby abandoned mansion to take refuge, but unbeknownst to them Team Rocket has as well. And both groups are frightened by strange occurrences through the house, all centered on a mysterious shadow.
Chespin gets fat after eating so many of Serena's macarons, so Clemont decides to put it on a diet by making an exercise machine and having it exercise through Pokémon Battles, but Chespin is not making progress.
Bonnie and another girl's bags get mixed up, leaving the other girl with Clemont's Dedenne and Bonnie with the girl's Pichu.
Ash and his friends meet up with Ninja Trainer Sanpei who owns a Frogadier. Ash challenges Sanpei to a series of ninja-training exercises, as Froakie learns a new move.
In Camphrier Town, Ash and his friends come across a Snorlax blocking their path. The local King Shabboneau has a Poké Flute that will wake it, but it was stolen by the selfish Princess Allie of Parfum Palace. Ash tries to retrieve it, but the princess demands a Pokémon Battle.
After Team Rocket attempts to consult the mysterious "Madame X" for help in capturing Pikachu, they are brainwashed by her Malamar, with only Meowth escaping and going to Ash and his friends for help. When Pikachu is captured and brainwashed as well, Ash, Serena, Clemont, Bonnie, and Meowth go to save him and Team Rocket. However, everyone but Ash and Meowth gets brainwashed, leaving them with no idea on how to stop Madame X.
Ash and his friends make it to the Battle Chateau where they participate in some matches while waiting for the battle between Viola and Cyllage City's Gym Leader Grant.
After watching a popular celebrity making a "PokéVision" video with her Pokémon, Serena tries to make one with her Fennekin.
Ash and his friends make it to Ambrette Town and marvel at its aquarium. They meet the aquarium's director Rodman and his partner Clauncher, and they try to help him complete the aquarium's collection by capturing a gold-colored Magikarp.
Ash, Serena, Clemont, and Bonnie meet up with Alexa again, who is covering the new fossil exhibit at the Ambrette Town Museum, meeting the revived fossil Pokémon Amaura and Aurorus in the museum's cold storage. However, Team Rocket arrives to steal Amaura, leaving Ash and his friends on a rescue mission.
Ash and his friends make it to Cyllage City, where Ash plans on challenging the Gym Leader Grant. Having already seen his strategy with Onix at the Battle Chateau, Ash plans on having Froakie face the Rock Pokémon in battle, and later Pikachu against Tyrunt.
While on the road, Serena makes some Poké Puffs for Pikachu and Fennekin, but her cooking skills are attacked by Miette, who has the Meringue Pokémon Slurpuff. The two decide to head to the next town and hold a Poké Puffs Contest to see who is the better pastry chef.
While brushing out her hair, Bonnie tries a new flower accessory, only to discover that a Flabébé is latching onto it because she has lost her Fairy Flower. The gang tries to help Flabébé get a new Fairy Flower, but it appears the season is over.
Upon arriving in the next town, Ash learns that the Kalos Region Champion Diantha will be holding an exhibition match, but he misses out on the sign up deadline. He heads to Professor Sycamore's lab, being tasked to help in his research on Mega Evolution, when he meets Diantha there by chance. She allows him a friendly match, Pikachu against her Gardevoir, and she shows she knows what Mega Evolution is.
Ash, Serena, and Bonnie must find out who has been impersonating them in the town they have just arrived in.
Ash and friends meet up with Korrina and her Lucario, and soon discover that she is the Shalour City Gym Leader, and she seems to possess a Mega Stone.
Ash, Serena, Clemont, and Bonnie help Korrina and her Lucario find the Mega Stone Lucarionite in Geosenge Town's caves, only to come face to face with a Blaziken protecting the caves.
Korrina finally finds the Lucarionite, but after using it, she loses control of Mega Lucario, who is much too strong for Pikachu to defeat. Her grandfather Gurkinn must step in and take care of matters, with his own Mega Lucario.
Korrina's grandfather Gurkinn tasks her with more training to rein in Mega Lucario, and Ash and company accompany her as they travel to Pomace Mountain only to fall into a trap laid by Team Rocket.
The group heads into the mountains around Pomace Mountain and meet with Mabel, a flower arranger who has mastered the art of Mega Evolution herself with her Mawile, prompting Korrina to have a friendly match.
Continuing on their journey to Shalour City, Ash and his friends come across the Wrestling Pokémon Hawlucha who is protecting a group of Pokémon in the forest from stronger Pokémon like Machamp, Conkeldurr and a Ursaring.
At Kalos Canyon, Ash learns of the Sky Battle trend and tries it out with Fletchling and Hawlucha against Sky Trainer Moria and her Talonflame.
While travelling in the Reflection Cave, Ash's reflection takes Pikachu away from him, prompting him to follow into a world within the reflection, leaving Clemont, Serena, and Bonnie to find a way to bring him back. After Ash arrives in the Mirror Dimension, he discovers that his mirror self needs help finding his Pikachu.
While practicing for his upcoming Gym battle against Korrina with Hawlucha, Froakie, and Clemont, Ash is kidnapped by the Elder Tree Pokémon Trevenant, leaving Froakie and Hawlucha to trust each other in saving Ash, as Trevenant keeps the others at bay with its power over the forest.
Ash, Serena, Clemont, and Bonnie make it to Professor Sycamore's Pokémon Summer Camp, where they meet Shauna, Trevor, and Tierno, who have received Bulbasaur, Charmander, and Squirtle from Professor Sycamore for their first Pokémon, and want to test their skills against Ash and his friends.
Serena and Shauna decide to have a little PokéVision contest, but while Serena was looking for locations with her friends, she and Ash become trapped at the bottom of a cliff.
The summer campers participate in a Pokémon Orienteering stamp rally where they must use their Pokémon to navigate through a course to get stamps at various stations. However, Bonnie and Pikachu get lost in the foggy woods and come across a mysterious Pokémon.
After all of the activities at the Pokémon Summer Camp, Ash's team and Tierno's team have the same amount of points. To settle the tie, all six will participate in a tag team match. But first, they have to save Tierno, Shauna, and Trevor's Pokémon from Team Rocket.
Before they have their Gym Battle, Ash and Korrina must stop Team Rocket after they have stolen a scroll on Mega Evolution from the Tower of Mastery.
Ash challenges Korrina for the Shalour Gym's Rumble Badge, with his Hawlucha, Fletchinder, and Pikachu facing off against her Mienfoo, Machoke, and Mega Lucario.
Bonnie and Clemont get into a fight after Bonnie wondered off to look for Chespin and when they encounter two brothers and their Meowstic having a rivalry, it gives Clemont a chance to teach Bonnie a lesson.
On their way to Coumarine City, the group goes to a Pokémon Center where Nurse Joy is assisted by a Wigglytuff with bad luck. However, they all soon find themselves having to deal with a Salamence that has gone out of control, and Wigglytuff is the only one who can save Joy.
After a Pancham disrupts a Pokémon Showcase and steals Ash's hat and Clemonts's glasses, Serena battles it with her Fennekin in an attempt to capture it and teach it some manners.
Clemont returns to his old school where he relives his younger years and reminisces about a Shinx he had befriended, but was forced to leave it behind after his graduation celebration. When he reunites with it, it has evolved into Luxio ever since and Clemont tries to heal the rift that was caused a few years ago.