Jesse Custer, a conflicted Preacher in a small Texas town who is inhabited by a mysterious entity that allows him to develop a highly unconventional power. Jesse, his ex-girlfriend, Tulip, and an Irish vampire named Cassidy embark on a journey to, literally, find God.
Jesse struggles to escape a past that is slowly catching up to him. Meanwhile, a mysterious entity comes to Earth, leaving a wave of destruction in its wake.
Jesse tries to be a "good preacher," unaware that a mysterious duo is after him. Meanwhile, the enigmatic Cowboy is introduced.
Cassidy helps Jesse explore his newfound power; based on new information, Tulip tries to convince Jesse to seek revenge.
Jesse makes Quincannon a bet he can't refuse; and Cassidy works to fend off the angels. Meanwhile, Tulip tries to bring justice to Annville.
Following his stunt, Jesse becomes Annville's newest rock star; Tulip and Cassidy connect; the Cowboy makes a decision.
Jesse finally comes face to face with Deblanc and Fiore and learns about the mysterious entity that has taken over his body.
Jesse's actions alienate and endanger those closest to him as we glimpse into his past and finally learn the root of all of his guilt.
Jesse protects his church in a vicious gun battle against Quincannon and the Meat Men; Tulip hopes to save a friend.
Jesse's in the wind while those close to him face life-changing decisions; the Cowboy comes back to Ratwater seeking his revenge.