What if an angel and a demon procreate? What would that offspring be? Would it be holy or demonic or both? Preacher is that tale. The offspring has no body, just a soul. That soul needs a body and chose Jesse Custer. A preacher from Texas with a loss of faith and a drinking problem. The offspring called Genesis bonds with Jesse, giving him the word of God. What he says is done.
Jesse is rocked by visions of an apocalyptic future as he and Tulip prepare for an all-out assault on Masada, where Cassidy - trapped to a torturous fate - struggles to hang on. But Starr and his Grail operatives are ready for them...
God maneuvers the chess pieces of His apocalypse closer to the endgame as Jesse searches for a mysterious rock formation that may be the final leg of his journey. Tulip devises a last-ditch effort to save Cassidy from his endless torture.
Tulip gets in too deep in Masada; Cassidy reflects on a lost life; the Saint closes in on Jesse.
Tulip forges an unexpected alliance to save Cassidy; Jesse finds himself stranded.
Tulip reunites with Cassidy and Eugene finds Jesse; the Grail's agenda threatens to unwind.
Tulip and Cass track Jesse and the Saint of Killers, while Starr searches for the missing messiah.
Tulip and Cass tear after God; an old friend presents Jesse with an unique opportunity.
Tulip and Cass struggle to keep Humperdoo hidden from the Grail, while Jesse remains MIA.
Jesse, Tulip and Cassidy mount one final assault on Masada as the Apocalypse Revue begins.