From the creators and executive producers of The Job comes Rescue Me, a drama/comedy that centers on the inner workings of Ladder Company 62, a New York City firehouse, and the personal and emotional battles of its members in a post-9/11 world. The show focuses Tommy Gavin, the senior fire-fighter whose life is in turmoil as he copes with the stresses and fears of his job as well the separation from his wife Janet. Tommy moves into a house across the street from her to stay close to their three children and keep an eye on her. The stresses and fears of his job are manifested through conversations with his dead cousin Jimmy Keefe, a former fire-fighter, as well as the haunting memories of people he has watched perish on the job. The remaining heroes of Ladder 62 include Chief Jerry Reilly who, despite being called "The Good Chief," has a serious gambling problem and bets on everything, even Tommy's divorce. Sean Garrity is a young, handsome guy who is easier to look at than hold a conversation with.
A terrifying vision of the afterlife leaves Tommy shaken as he attempts to reconnect with his friends and family back on the outside. At the firehouse, the crew’s fate hangs in the balance when the department decides to cut costs.
Tommy comes to terms with his nightmare and tries to do right by those around him, but his plans fall by the wayside when the gang gathers at the bar post save.
Tommy's first day back on the job is a busy one as the crew races from call to call. By the end of the shift, the guys are all exhausted, but it's Lou who feels it the most.
With the cookout quickly approaching, the guys hatch a plan to sneak Lou out of the hospital. Sean and Mike attempt to do good, Teddy bonds with Colleen, and Father Phil gives Tommy a piece of advice that sends him reeling.
A night of heavy drinking turns ugly when Tommy blacks out and loses control. The next day, the crew struggles to put the pieces together as they search for the whereabouts of Colleen.
Tommy loses his nerve when a young driver's recklessness reminds him of his daughter's new lifestyle. After a meeting fails to put Colleen on the wagon, Tommy is forced to pursue a more aggressive method to get her life back on track.
When headquarters shuts down the house, the crew formulates a makeshift response to a nearby call. A face from the past stirs Tommy and Janet's emotions as their date begins to unravel.
Needles' political leverage catches HQ off guard, leaving them no choice but to reopen the house. Feinberg loses control, Damian saves a helpless victim, and Tommy and Sheila find themselves in hot water.
Tommy and Sheila find themselves in hot water with Janet and Mickey and realize the truth about their own relationship. Damian attempts to leave the crew, but is seduced back by the camaraderie of the brotherhood.