From the creators and executive producers of The Job comes Rescue Me, a drama/comedy that centers on the inner workings of Ladder Company 62, a New York City firehouse, and the personal and emotional battles of its members in a post-9/11 world. The show focuses Tommy Gavin, the senior fire-fighter whose life is in turmoil as he copes with the stresses and fears of his job as well the separation from his wife Janet. Tommy moves into a house across the street from her to stay close to their three children and keep an eye on her. The stresses and fears of his job are manifested through conversations with his dead cousin Jimmy Keefe, a former fire-fighter, as well as the haunting memories of people he has watched perish on the job. The remaining heroes of Ladder 62 include Chief Jerry Reilly who, despite being called "The Good Chief," has a serious gambling problem and bets on everything, even Tommy's divorce. Sean Garrity is a young, handsome guy who is easier to look at than hold a conversation with.
With Damian confined to a chair and a new baby on the way, Sheila and Janet join forces and shake-up Tommy’s family life.
The guys go stir crazy waiting to catch a job. Lou fakes his physical, a news team memorializes Jimmy, and Tommy is saved by an unfamiliar face.
Tommy swoops into action, putting an end to Kelly's dull date and to his spell of uselessness. Lou becomes godfather, Colleen finds a dress, and Tommy sits down for his interview.
What starts as a controlled interview takes a turn for the worse, ending in a full-on brawl. The beef continues even after the guys survive a harrowing scenario at a call.
Tommy has his badge revoked when his latest tirade goes national. But Sheila’s two-pronged attack hits Tommy’s critics where they least expect it, vindicating Tommy and clearing the Gavin family name.
A day at ground zero inspires Tommy to write letters to his loved ones. When Lou betrays his trust, Tommy returns to ground zero with an old friend.
Franco demands a sense of responsibility around the house, but a precarious call puts his leadership skills to the test. Lou delivers Tommy's letters unbeknownst to Tommy.
In the tradition of the Gavin family, Colleen's wedding is an emotional if not debaucherous affair. The high spirits quickly fade, however, when the guys tackle the mother of all fires.