An ensemble comedy that follows the chaotic life of George Lopez, a recently divorced working class Mexican-American turned successful entrepreneur caught between two cultures. He struggles to balance the parenting demands of his All-American Anglo ex-wife Mackenzie and the cultural expectations of his overbearing Mexican-American mother Alma.
As George attempts to relate to his 11-year-old son Harper, his life is further complicated by his fun-loving but freeloading uncle Tio and cousin Junior. As a wealthy businessman, George also gives back by teaching history to a multi-cultural classroom at a night school in downtown Los Angeles, where he's supervised by tough and sexy Assistant Principal Concepcion. Ultimately, Saint George is a celebration of a multi-generational family that humorously wrestles with cultural differences.
George re-enters the dating scene after his divorce, and the results are terrible, in the premiere of this sitcom about a successful Mexican-American entrepreneur whose life is made chaotic by his multi-generational family.
George is determined to have an old-school Mexican birthday party for Harper, which ends in chaos with the police showing up.
After being pushed and pulled by family members, George discovers he's been ignoring the one who needs him most - his son.
Alma is convinced that Harper is not George's son and orders a DNA test to prove it.
Alma falls, and George has to become nursemaid to the patient from hell.
George kicks Alma out of his house and discovers he misses fighting with her.
Alma sets George up on a date with a Latina doctor, and George discovers the woman is crazy.
George and Mackenzie's bickering over Harper attending private school reminds them why they got a divorce.