Ages ago, the goddess Athena was served by fighters called Saints who channeled the power of the Cosmos within them. Now a youth named Seiya has trained to become a Saint himself by earning the mystical Cloth of Pegasus. He is joined by other Saints with Cloths of their own to fight for Athena.
The Crusades. The battles that take place every 200 or so years between the Goddess Athena and Hades, the Lord of the Underworld. In an 18th century European country town, just as the Crusade is dawning, live Tenma and Alone. They have completely different personalities but are the best of friends. One day, Alone meets a woman named Pandora. From that day, the cogs of fate are set into motion.
Tenma and the other Saintly Warriors head towards an Italian town where the warriors of the Underworld are gathered. Tenma realizes it is his hometown, and worries about Tenma’s fate. However, Alone appears amongst the burning ruins of the town as the reincarnation of Lord Hades. Tenma – shocked by the evil transformation of his dear friend – is mercilessly attacked by Alone
One of the three strongest Specters, Minos, uses invisible puppet strings to invade the supposedly impenetrable Sanctuary, killing Saints off one after the other. However, a poisonous rose garden appears between Minos and the Sanctuary. Pisces Golden Saint Albafica appears in the middle of the garden. Albafica is immune to the rose’s poison, and uses his own blood to kill the Specter Niobe, however…
Albafica fights against Minos with all his might, releasing the “crimson zone.” However even that is deflected by the Specter’s armor, causing Albafica to finally fall. Minos then heads towards the village outside of the Sanctuary that Albafica was trying to protect. The village is destroyed, and even Agasya, a young girl mourning Albafica, is targeted by Minos.
Yuzuriha reveals to Tenma and Yato that their real mission is to pick the fruits of the legendary Sapindus that grows in the underworld. On their way, they are found by Hell's Watchdog Cerberus and Alone, who tries to lure the Pegasus Saint into his army and then reveals his plans to invade the Sanctuary. As the last and most unexpected obstacle, Tenma is challenged by ominous Virgo Asmita, that seems to doubt Athena's capacity to keep peace in the world.
Tenma bears the full force of Asmita’s attack. When suddenly the Goldenrain reacts to Tenma’s rising cosmos and bears fruit. Asmita disappears, and Tenma and the others gather the berries and flee from the Underworld. However, even Jamir feels the evil reach of new Specters. Who should appear before them but Asmita.
Minos's Specters, previously killed by Pisces Albafica's Bloody Rose trap, are brought back to life. Now, they find themselves face to face with Taurus Aldebaran, who proves to be capable of dealing with them with his arms crossed. While Aldebaran and Dohko patrol the Sanctuary's vicinity, Bennu Kagaho arrives, seeking revenge against the Libra Saint — however, he meets Taurus instead, and they start a furious battle: the fastest Specter against the fastest Gold Saint.
The fight between Aldebaran and Kagaho reaches its climax. Bennu recalls old memories with the arrival of the Taurus Saint's disciples, and decides to take on his opponent with full power; on the other hand, Aldebaran decides to unleash his most powerful technique in order to end the battle. During the night, peace is shaken: Alone himself invades the Sanctuary and wreaks destruction, forcing the Gold Saints into submission with his tenebrous cosmo. It's time for Athena to face her legendary enemy — and for Sasha, to face her older brother.
Tenma finally returns to the Sanctuary, and challenges Alone to a fight, only to have the tables turned. Then, the Pope arrives and uses an amulet from a previous incarnation of Athena to release the “Talisman Cage” and weaken Hades’ power. He tries to seal Hades in the Sanctuary using Athena’s cosmos. However, Pandora rushes over…
The painting covering the whole sky, “The Lost Canvas,” is said to destroy everyone on earth when completed. Tenma hears to his dismay that the once kind Alone is now trying to destroy all of humanity as Hades. Meanwhile, Pandora desperately realizes that the reincarnation of Hades is incomplete, and sends an assassin to kill Tenma, who is stopping the completion of the reincarnation. The Specters use ultrasonic waves to put Tenma and the others asleep, however…
Tenma leaves the Sanctuary and has resolved to fight on his own. However, on orders from the Pope, he is stopped by the Cancer Golden Saint Manigold and locked in a cell. Back at the Hades palace, so as to fully awaken Hades, who’s full reincarnation is prevented by Alone’s memories, Hypnos and Thanatos encourage Pandora to trap Hades into an atrium.