Samantha "Sam" Newly is a corporate executive and hit-and-run victim who awakens after being in a coma for eight days, only to find she has amnesia. With no memories of the past, she must rediscover everything about her life and herself by looking for clues from her past.
Sam finds out she was a dancer before she contracted amnesia, which prompts her to join her mother in the fight against her mother's nemesis (Cybil Shepherd) in the annual dance contest at the country club. Meanwhile, Todd drags his feet in vacating Sam's place because of his financial ability to secure a new place of his own.
The new Sam decides to take a trip to Africa in hopes of providing some help to people who desperately need it, but then chickens out when she finds out what it's going to take to get there.
Desperate to regain her memory, Sam opts to join a clinical trial and starts taking pills for her memory. Sam's memories start coming back, but she doesn't like what she learns about her former self. Elsewhere, someone confuses Dena and Andrea as being a gay couple, which frustrates Andrea and sends her on the hunt to find someone hotter than Dena.
After pointing out her serious cash-flow problem, Samantha's mother gets her to agree to get back into the real estate game, only this time with her mother. Andrea attempts to use Todd's friend to further her own gold-digging excursions.
After being given community service for her altercation with a cop, Sam tries to help out Natalie, a wayward young woman, despite pleas from her friends not to. Howard tries to give Todd advice on how to win Sam back, even though he told Howard he wasn't interested anymore.
Sam thinks it's all right for Todd to be in her life as a friend while dating Owen, but doesn't like the idea of Owen's ex, Willow, being Owen's best friend. Meanwhile, Andrea gets Dena to take pictures of her in hopes of landing a professional basketball player.
Samantha invites Owen to dinner to meet her parents; Dena worries that Chase isn't spending enough time with her; Todd asks Samantha to stay at her parents' house while his mother is in town.
Sam tries to make herself appear to be an environmentalist, so Owen might like her more. Andrea doesn't fare well when the basketball player, Tony Dane, is looking for a date.
After the breakup between Owen and Sam, The Newlys, Dena, and Andrea decide to pack it up and head out for an overdue family vacation to a lodge. Sam is met by an unexpected friend at the lodge, Brad, who was her childhood sweetheart. Things get turbulent when Andrea makes a pass at him.
Andrea has a new boyfriend and Sam wants the couple to actually go on a real date for once. Todd doesn't like being just the roommate. Dena has a new penpal in Iraq, but she wonders if it means she's cheating on Chase.
When Sam feels her biological clock ticking away and realizes her desire to be a mother, she tries to probe her own motherly instincts by borrowing Dena's dog to find out if she's nurturing enough to care for and love it. Meanwhile, Regina attempts pilot lessons when she learns that Howard's late step-brother has willed them a plane, and Andrea continues to fuel the tabloid fires while she dates famous pro-basketball star Tony Dane.
Sam tries to become friends with Frank, once she thinks her old self was a racist. Andrea doesn't want to lose all the glamour of dating a celebrity, after Tony is outed as being gay.
Sam loses big at the craps table in Vegas. But a chance meeting with her ex-boss, billionaire Winston Funk, could be the answer to her financial dilemma.
Sam dates a rock star to whom Dena and Andrea take a liking. Their unruly behavior toward Sam's new beau causes Sam to inch farther and farther away from her friends.
Thinking she already ruined one job for him, Sam tries to secretly help Todd out by distracting the competition up for the same job as Todd. Unbeknownst to Dena, Regina tries to sell Dena's house, so that she can still work with Sam.
Sam discovers that a family heirloom is the reason why her mom was in a feud with her sister and a mother, that Sam didn't know she had. Andrea is viewed as a jinx to Tony's team, after they start losing when she is there.
Sam becomes the head of the charity foundation for Winston Funk and hires Andrea as her vice president of legal affairs. She soon regrets this idea when Andrea shirks her duties in favor of planning her wedding.
Sam decides to give Todd a second chance by going out with him on another "first date," but Todd doesn't trust Winston Funk, believing he and Sam may continue the affair they were having before the accident. Meanwhile, Andrea appears on a reality TV series about celebrity weddings, along with her gay basketball star Tony Dane.
Samantha vaguely remembers something about Winston Funk's ex wife Gigi before the accident. Chapman tries to ask Dena to marry him. Andrea tries to lure Tony Dane into bed. Regina is caught in a love triangle as she prepares to leave on vacation with Howard.
It's Andrea's wedding day! While Andrea has chosen her life partner, Samantha has to make a decision as to who she wants to be with. Will it be debonaire millionaire Winston Funk or her not-rich-but-ever-reliable ex-boyfriend Todd. Even Sam's parents are at a crossroad as Regina and Howard begin to take separate paths.