Save Me is a web-toon based thriller drama with a story of four young men who try to save one woman. One day, they face a woman in a dark alley who asks for their help. The woman turns out to be involved in a cult group. A sequence of horrifying tension-filled events follow the four young men.
Sang Mi and her family moves to Muji-gun where she has no friends or relatives. While moving, the tire of their car blows out. The four youths who were passing by the road give them a hand. Meanwhile, the followers of Spiritual Father Baek Jung Ki are mesmerized by his power and words. What could be going on in this mysterious town?
Spiritual Father helps Sang Mi’s family move into a decent house and they feel much gratitude towards everyone at Guseonwon. Joo Ho even offers Apostle Kang his kids to help with the volunteer work. Meanwhile, Sang Mi and Sang Jin start their first day at school. Sang Jin gets bullied by the kids and Sang Mi asks Sang Hwan to help her brother.
Dong Cheol gets arrested for being involved in Sang Jin’s death. Sang Hwan seeks for help, but his dad asks him to do nothing as it might hurt his election. Joo Ho goes after the boys who hurt Sang Jin, but gets badly hurt. Meanwhile, Apostle Kang and Apostle Jo visit Sang Mi’s house to pray for their family.
Bo Eun loses her mind after Sang Jin’s death. Joo Ho looks for every mean to fix his wife, but her condition keeps getting worse. Joo Ho is grateful to everyone at Guseonwon that he falls for the religion they’re preaching. Meanwhile, Sang Hwan and his friends meet up after three years. Sang Mi is still living under Guseonwon’s help even after three years.
Sang Mi tries to escape Guseonwon with Jeong Gu and their lives are at stake. During the escape, Jeong Gu gets into a terrible accident. Spiritual Father thinks it’d be better if Sang Mi lives alone outside for a while, but Apostle Jo goes against it. Meanwhile, Dong Cheol gets out of prison after serving for three years.
Sang Mi gets locked up in a new house and Joo Ho guards her day and night. Sang Hwan thinks Sang Mi really needs help this time, so he asks her if she’s in need of help. Meanwhile, Dong Cheol starts working in a nightclub where he meets some familiar faces.
Sang Mi gets chosen by Spiritual Father to become Spiritual Mother. She tries to kill herself in front of everyone, but Spiritual Father threatens her by saying he will hurt her mother. Meanwhile, Sang Hwan finds Dong Cheol and tries making up with him, but Dong Cheol strongly refuses to do so.
Sang Mi reaches out to Sang Hwan for help. Remembering what he did three years ago, Sang Hwan makes up his mind not to run away this time. Will they be able to save Sang Mi in time before she becomes the Spiritual Mother?
The gang manages to rescue Sang Mi. They take her to a local police station so that the police can start an investigation. Will Sang Mi finally be free from Guseonwon? Meanwhile, Joon Gu asks Dong Cheol for help.
Sang Mi states that she came back to Guseonwon by her own will, with intents to bring her mother back. With the gang’s first attempt gone to failure, Dong Cheol tries a different approach. Meanwhile, Spiritual Father reveals his true colors.
Pastor Baek prepares to welcome Sang Mi as Spiritual Mother. At Guseonwon, Dong Cheol meets someone who is also looking for what’s hidden in that place. With the day of the spiritual wedding approaching, the gang gets ready to get Sang Mi out once and for all.
Guseonwon reveals its true color. In the woods near Guseonwon, a dead body is found, and Kang Su finds this suspicious. While looking into a way to expose Guseonwon, the gang finds a lead. Meanwhile, Sang Mi asks the question she’s been seeking an answer to.
Pastor Baek reveals his true intentions. Seeking help from the police, Sang Hwan goes to Kang Su. With Dong Cheol and the undercover journalist helping Sang Mi from inside, Sang Mi slowly starts to see hope. Meanwhile, Apostle Jo finds out about the internet broadcast.
Dong Cheol convinces Dae Sik and makes it look like he protected Sang Mi from harm. Meanwhile, Apostle Jo and Apostle Kang get into a conflict. Apostle Kang decides to get rid of the demons hiding in Guseonwon.
When So Rin doesn’t show up, Sang Hwan senses that something went wrong. Dong Cheol suspects Aspotle Jo and looks into what happened. In order to save Sang Mi from Guseonwon, Sang Hwan decides to corner his own dad.
The spiritual wedding is about to begin. In order to save everyone held captive and to expose Guseonwon, Dong Cheol executes his plan. Will the gang be able to take down Guseonwon and save Sang Mi once and for all?